Literature DB >> 26000854

SnapShot: Kinase Inhibitors I.

Jinhua Wang1, Nathanael S Gray1.   

Abstract

Selective small-molecule inhibitors of protein kinases can serve as powerful tools to elucidate biological function. Efforts to develop potential drug candidates have yielded a wealth of kinase inhibitors. However, selecting the optimal kinase inhibitor for a particular application can be challenging. While the optimal inhibitor will be application specific, we have attempted to summarize some of the best reported inhibitors for various kinases.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID: 26000854     DOI: 10.1016/j.molcel.2015.05.001

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  4 in total

1.  Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.

Authors:  Nienke Moret; Nicholas A Clark; Marc Hafner; Yuan Wang; Eugen Lounkine; Mario Medvedovic; Jinhua Wang; Nathanael Gray; Jeremy Jenkins; Peter K Sorger
Journal:  Cell Chem Biol       Date:  2019-04-04       Impact factor: 8.116

2.  Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.

Authors:  Devon R Blake; Angelina V Vaseva; Richard G Hodge; McKenzie P Kline; Thomas S K Gilbert; Vikas Tyagi; Daowei Huang; Gabrielle C Whiten; Jacob E Larson; Xiaodong Wang; Kenneth H Pearce; Laura E Herring; Lee M Graves; Stephen V Frye; Michael J Emanuele; Adrienne D Cox; Channing J Der
Journal:  Sci Signal       Date:  2019-07-16       Impact factor: 8.192

3.  OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases.

Authors:  Wenbin Ji; Christopher Arnst; Aaron R Tipton; Michael E Bekier; William R Taylor; Tim J Yen; Song-Tao Liu
Journal:  PLoS One       Date:  2016-04-15       Impact factor: 3.240

4.  Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.

Authors:  Antonio P A Ferreira; Alessandra Casamento; Sara Carrillo Roas; Els F Halff; James Panambalana; Shaan Subramaniam; Kira Schützenhofer; Laura Chan Wah Hak; Kieran McGourty; Konstantinos Thalassinos; Josef T Kittler; Denis Martinvalet; Emmanuel Boucrot
Journal:  Nat Commun       Date:  2021-04-23       Impact factor: 14.919

  4 in total

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