| Literature DB >> 26000652 |
Ruthy Tal Jasper1, Joseph R Coyle, David E Katz2, Dror Marchaim1,3.
Abstract
Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum β-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum β-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.Entities:
Keywords: E. coli; Gram negative; Klebsiella pneumoniae; MDROs; Proteus mirabilis; ST-131; antibiotic stewardship; carbapenem; community acquired; healthcare associated
Mesh:
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Year: 2015 PMID: 26000652 DOI: 10.2217/fmb.15.16
Source DB: PubMed Journal: Future Microbiol ISSN: 1746-0913 Impact factor: 3.165