Literature DB >> 26000472

A CRISPR Connection between Chromatin Topology and Genetic Disorders.

Bing Ren1, Jesse R Dixon2.   

Abstract

Structural variations are common in the human genome, but their contributions to human diseases have been hard to define. Lupiáñez et al. demonstrate that some structural variants can interrupt chromatin topology, resulting in ectopic enhancer-promoter interactions, altered spatiotemporal gene expression patterns, and developmental disorders.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26000472      PMCID： PMC4478077          DOI： 10.1016/j.cell.2015.04.047

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation.

Authors:  Varun Narendra; Pedro P Rocha; Disi An; Ramya Raviram; Jane A Skok; Esteban O Mazzoni; Danny Reinberg
Journal:  Science       Date:  2015-02-27       Impact factor: 47.728

Review 2.  Structural variation in the human genome and its role in disease.

Authors:  Paweł Stankiewicz; James R Lupski
Journal:  Annu Rev Med       Date:  2010       Impact factor: 13.739

Review 3.  The role of chromosome domains in shaping the functional genome.

Authors:  Tom Sexton; Giacomo Cavalli
Journal:  Cell       Date:  2015-03-12       Impact factor: 41.582

Review 4.  CTCF: an architectural protein bridging genome topology and function.

Authors:  Chin-Tong Ong; Victor G Corces
Journal:  Nat Rev Genet       Date:  2014-03-11       Impact factor: 53.242

5.  Ectodermal Wnt-6 promotes Myf5-dependent avian limb myogenesis.

Authors:  Poongodi Geetha-Loganathan; Suresh Nimmagadda; Felicitas Pröls; Ketan Patel; Martin Scaal; Ruijin Huang; Bodo Christ
Journal:  Dev Biol       Date:  2005-11-02       Impact factor: 3.582

6.  A switch between topological domains underlies HoxD genes collinearity in mouse limbs.

Authors:  Guillaume Andrey; Thomas Montavon; Bénédicte Mascrez; Federico Gonzalez; Daan Noordermeer; Marion Leleu; Didier Trono; François Spitz; Denis Duboule
Journal:  Science       Date:  2013-06-07       Impact factor: 47.728

7.  Spatial partitioning of the regulatory landscape of the X-inactivation centre.

Authors:  Elphège P Nora; Bryan R Lajoie; Edda G Schulz; Luca Giorgetti; Ikuhiro Okamoto; Nicolas Servant; Tristan Piolot; Nynke L van Berkum; Johannes Meisig; John Sedat; Joost Gribnau; Emmanuel Barillot; Nils Blüthgen; Job Dekker; Edith Heard
Journal:  Nature       Date:  2012-04-11       Impact factor: 49.962

8.  Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.

Authors:  Darío G Lupiáñez; Katerina Kraft; Verena Heinrich; Peter Krawitz; Francesco Brancati; Eva Klopocki; Denise Horn; Hülya Kayserili; John M Opitz; Renata Laxova; Fernando Santos-Simarro; Brigitte Gilbert-Dussardier; Lars Wittler; Marina Borschiwer; Stefan A Haas; Marco Osterwalder; Martin Franke; Bernd Timmermann; Jochen Hecht; Malte Spielmann; Axel Visel; Stefan Mundlos
Journal:  Cell       Date:  2015-05-07       Impact factor: 41.582

9.  Topological domains in mammalian genomes identified by analysis of chromatin interactions.

Authors:  Jesse R Dixon; Siddarth Selvaraj; Feng Yue; Audrey Kim; Yan Li; Yin Shen; Ming Hu; Jun S Liu; Bing Ren
Journal:  Nature       Date:  2012-04-11       Impact factor: 49.962

10.  Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling.

Authors:  Y Yang; P Guillot; Y Boyd; M F Lyon; A P McMahon
Journal:  Development       Date:  1998-08       Impact factor: 6.868
  10 in total
  1 in total

1.  Fine-Scale Position Effects Shape the Distribution of Inversion Breakpoints in Drosophila melanogaster.

Authors:  Jakob McBroome; David Liang; Russell Corbett-Detig
Journal:  Genome Biol Evol       Date:  2020-08-01       Impact factor: 3.416
  1 in total

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