Literature DB >> 26000468

Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors.

Maren Kuhnert1, Andreas Blum1, Holger Steuber2, Wibke E Diederich1.   

Abstract

3,4-disubstituted pyrrolidines originally designed to inhibit the closely related HIV-1 protease were evaluated as privileged structures against HTLV-1 protease (HTLV-1 PR). The most potent inhibitor of this series exhibits two-digit nanomolar affinity and represents, to the best of our knowledge, the most potent nonpeptidic inhibitor of HTLV-1 PR described so far. The X-ray structures of two representatives bound to HTLV-1 PR were determined, and the structural basis of their affinity is discussed.

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Year:  2015        PMID： 26000468     DOI： 10.1021/acs.jmedchem.5b00346

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  Comparative study of the unbinding process of some HTLV-1 protease inhibitors using unbiased molecular dynamics simulations.

Authors:  Fereshteh Noroozi Tiyoula; Hassan Aryapour; Mostafa Javaheri Moghadam
Journal:  PLoS One       Date:  2022-07-14       Impact factor: 3.752

2.  Enantioselective C-H Amination Catalyzed by Nickel Iminyl Complexes Supported by Anionic Bisoxazoline (BOX) Ligands.

Authors:  Yuyang Dong; Colton J Lund; Gerard J Porter; Ryan M Clarke; Shao-Liang Zheng; Thomas R Cundari; Theodore A Betley
Journal:  J Am Chem Soc       Date:  2021-01-04       Impact factor: 16.383

3.  Dimer Interface Organization is a Main Determinant of Intermonomeric Interactions and Correlates with Evolutionary Relationships of Retroviral and Retroviral-Like Ddi1 and Ddi2 Proteases.

Authors:  János András Mótyán; Márió Miczi; József Tőzsér
Journal:  Int J Mol Sci       Date:  2020-02-17       Impact factor: 5.923

4.  Biochemical Characterization, Specificity and Inhibition Studies of HTLV-1, HTLV-2, and HTLV-3 Proteases.

Authors:  Norbert Kassay; János András Mótyán; Krisztina Matúz; Mária Golda; József Tőzsér
Journal:  Life (Basel)       Date:  2021-02-06

5.  Synthesis of bioactive fluoropyrrolidines via copper(i)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides.

Authors:  Xiao Xu; Longzhu Bao; Lu Ran; Zhenyan Yang; Dingce Yan; Chun-Jiang Wang; Huailong Teng
Journal:  Chem Sci       Date:  2021-12-07       Impact factor: 9.825

6.  Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives.

Authors:  Xin Chang; Xiang Cheng; Chun-Jiang Wang
Journal:  Chem Sci       Date:  2022-03-17       Impact factor: 9.825

7.  Enantioselective 1,3-Dipolar Cycloaddition Using (Z)-α-Amidonitroalkenes as a Key Step to the Access to Chiral cis-3,4-Diaminopyrrolidines.

Authors:  Eduardo García-Mingüens; Marcos Ferrándiz-Saperas; M de Gracia Retamosa; Carmen Nájera; Miguel Yus; José M Sansano
Journal:  Molecules       Date:  2022-07-18       Impact factor: 4.927

8.  Inhibiting HTLV-1 Protease: A Viable Antiviral Target.

Authors:  Gordon J Lockbaum; Mina Henes; Nathaniel Talledge; Linah N Rusere; Klajdi Kosovrasti; Ellen A Nalivaika; Mohan Somasundaran; Akbar Ali; Louis M Mansky; Nese Kurt Yilmaz; Celia A Schiffer
Journal:  ACS Chem Biol       Date:  2021-02-23       Impact factor: 5.100
  8 in total

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