Literature DB >> 25999654

Real-time treatment light dose guidance of Pleural PDT: an update.

Timothy C Zhu1, Michele M Kim2, Steve L Jacques3, Rozhin Penjweini1, Andreea Dimofte1, Jarod C Finlay1, Charles B Simone1, Keith A Cengel1, Joseph Friedberg4.   

Abstract

The goal of this study was to develop and improve an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, several detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. Monte-Carlo simulation is used to improve the calculation algorithm for the effect of light that undergoes multiple scattering along the surface in addition to an improvement of the direct light calculation using an improved model that accounts for the anisotropy of the light from the light source.

Entities:  

Keywords:  MC simulation; Photodynamic therapy; intra-cavitary treatment planning; light dosimetry; light fluence

Year:  2015        PMID： 25999654      PMCID： PMC4437627          DOI： 10.1117/12.2080110

Source DB:  PubMed          Journal:  Proc SPIE Int Soc Opt Eng        ISSN： 0277-786X


  9 in total

1.  Intraoperative photodynamic therapy for malignant mesothelioma.

Authors:  H I Pass; Z Tochner; T DeLaney; P Smith; W Friauf; E Glatstein; W Travis
Journal:  Ann Thorac Surg       Date:  1990-10       Impact factor: 4.330

2.  An IR navigation system for real-time treatment guidance of Pleural PDT.

Authors:  Timothy C Zhu; Xing Liang; Chang Chang; Julia Sandell; Jarod C Finlay; Andreea Dimofte; Carmen Rodrigeus; Keith Cengel; Joseph Friedberg; Eli Glatstein; Stephen M Hahn
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2011-02-28

3.  Anisotropic modeling for IR navigation-based PDT dosimetry.

Authors:  Michele M Kim; Xing Liang; Timothy C Zhu
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2014-02-01

4.  Real-time treatment feedback guidance of Pleural PDT.

Authors:  Timothy C Zhu; Michele M Kim; Xing Liang; Baochang Liu; Julia L Meo; Jarod C Finlay; Andreea Dimofte; Carmen Rodriguez; Charles B Simone; Keith Cengel; Joseph S Friedberg
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2013-02-02

5.  MCML--Monte Carlo modeling of light transport in multi-layered tissues.

Authors:  L Wang; S L Jacques; L Zheng
Journal:  Comput Methods Programs Biomed       Date:  1995-07       Impact factor: 5.428

6.  In vivo light dosimetry for motexafin lutetium-mediated PDT of recurrent breast cancer.

Authors:  Andreea Dimofte; Timothy C Zhu; Stephen M Hahn; Robert A Lustig
Journal:  Lasers Surg Med       Date:  2002       Impact factor: 4.025

Review 7.  Photodynamic therapy for lung cancer and malignant pleural mesothelioma.

Authors:  Charles B Simone; Keith A Cengel
Journal:  Semin Oncol       Date:  2014-10-07       Impact factor: 4.929

8.  OpenIGTLink: an open network protocol for image-guided therapy environment.

Authors:  Junichi Tokuda; Gregory S Fischer; Xenophon Papademetris; Ziv Yaniv; Luis Ibanez; Patrick Cheng; Haiying Liu; Jack Blevins; Jumpei Arata; Alexandra J Golby; Tina Kapur; Steve Pieper; Everette C Burdette; Gabor Fichtinger; Clare M Tempany; Nobuhiko Hata
Journal:  Int J Med Robot       Date:  2009-12       Impact factor: 2.547

9.  Intrapleural photodynamic therapy: results of a phase I trial.

Authors:  H I Pass; T F DeLaney; Z Tochner; P E Smith; B K Temeck; H W Pogrebniak; K C Kranda; A Russo; W S Friauf; J W Cole
Journal:  Ann Surg Oncol       Date:  1994-01       Impact factor: 5.344
  9 in total
  8 in total

1.  Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT).

Authors:  Timothy C Zhu; Yihong Ong; Michele M Kim; Xing Liang; Jarod C Finlay; Andreea Dimofte; Charles B Simone; Joseph S Friedberg; Theresa M Busch; Eli Glatstein; Keith A Cengel
Journal:  Photochem Photobiol       Date:  2019-10-22       Impact factor: 3.421

2.  Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method.

Authors:  Rozhin Penjweini; Michele M Kim; Andrea Dimofte; Jarod C Finlay; Timothy C Zhu
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2016-03-07

3.  Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy.

Authors:  Rozhin Penjweini; Michele M Kim; Timothy C Zhu
Journal:  Med Phys       Date:  2017-05-24       Impact factor: 4.071

4.  A summary of light dose distribution using an IR navigation system for Photofrin-mediated Pleural PDT.

Authors:  Timothy C Zhu; Michele M Kim; Yi-Hong Ong; Rozhin Penjweini; Andreea Dimofte; Jarod C Finlay; Carmen Rodriguez; Keith A Cengel
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2017-02-21

5.  Infrared navigation system for light dosimetry during pleural photodynamic therapy.

Authors:  Michele M Kim; Timothy C Zhu; Yi Hong Ong; Jarod C Finlay; Andreea Dimofte; Sunil Singhal; Eli Glatstein; Keith A Cengel
Journal:  Phys Med Biol       Date:  2020-04-14       Impact factor: 3.609

6.  Real-time PDT Dose Dosimetry for Pleural Photodynamic Therapy.

Authors:  Timothy C Zhu; Hongjing Sun; Yi-Hong Ong; Ryan Hall Morales; Andreea Dimofte; Theresa Busch; Sunil Singhal; Keith A Cengel
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2022-03-04

7.  A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma.

Authors:  Stephanie R Rice; Yun R Li; Theresa M Busch; Michele M Kim; Sally McNulty; Andrea Dimofte; Timothy C Zhu; Keith A Cengel; Charles B Simone
Journal:  Photochem Photobiol       Date:  2018-12-28       Impact factor: 3.421

Review 8.  Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies.

Authors:  Angela Bononi; Andrea Napolitano; Harvey I Pass; Haining Yang; Michele Carbone
Journal:  Expert Rev Respir Med       Date:  2015-08-26       Impact factor: 3.772
  8 in total

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