Literature DB >> 25999419

Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.

Opher S Kornfeld1, Sunhee Hwang1, Marie-Hélène Disatnik1, Che-Hong Chen1, Nir Qvit1, Daria Mochly-Rosen2.   

Abstract

Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
© 2015 American Heart Association, Inc.

Entities:  

Keywords:  mitochondria; mitochondrial degradation; mitochondrial dynamics; protein kinase C; reactive oxygen species

Mesh：

Substances：

Year:  2015        PMID： 25999419      PMCID： PMC4443500          DOI： 10.1161/CIRCRESAHA.116.305432

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  172 in total

1.  Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation.

Authors:  Ami P Raval; Kunjan R Dave; Ricardo Prado; Laurence M Katz; Raul Busto; Thomas J Sick; Myron D Ginsberg; Daria Mochly-Rosen; Miguel A Pérez-Pinzón
Journal:  J Cereb Blood Flow Metab       Date:  2005-06       Impact factor: 6.200

Review 2.  Mitochondria in vascular health and disease.

Authors:  Peter Dromparis; Evangelos D Michelakis
Journal:  Annu Rev Physiol       Date:  2012-11-16       Impact factor: 19.318

3.  Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

Authors:  F Di Lisa; R Menabò; M Canton; M Barile; P Bernardi
Journal:  J Biol Chem       Date:  2000-11-09       Impact factor: 5.157

Review 4.  Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors.

Authors:  Gerald W Dorn
Journal:  J Cardiovasc Transl Res       Date:  2010-03-16       Impact factor: 4.132

5.  Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.

Authors:  Katia M S Gomes; Luiz R G Bechara; Vanessa M Lima; Márcio A C Ribeiro; Juliane C Campos; Paulo M Dourado; Alicia J Kowaltowski; Daria Mochly-Rosen; Julio C B Ferreira
Journal:  Int J Cardiol       Date:  2014-10-23       Impact factor: 4.164

6.  Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Authors:  Glenn Marsboom; Peter T Toth; John J Ryan; Zhigang Hong; Xichen Wu; Yong-Hu Fang; Thenappan Thenappan; Lin Piao; Hannah J Zhang; Jennifer Pogoriler; Yimei Chen; Erik Morrow; E Kenneth Weir; Jalees Rehman; Stephen L Archer
Journal:  Circ Res       Date:  2012-04-17       Impact factor: 17.367

7.  Protein Oxidative Modifications: Beneficial Roles in Disease and Health.

Authors:  Zhiyou Cai; Liang-Jun Yan
Journal:  J Biochem Pharmacol Res       Date:  2013-03

Review 8.  Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury.

Authors:  Elizabeth Murphy; Charles Steenbergen
Journal:  Physiol Rev       Date:  2008-04       Impact factor: 37.312

Review 9.  Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent.

Authors:  Derek J Hausenloy; E A Boston-Griffiths; D M Yellon
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

10.  Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

Authors:  Edward T Chouchani; Carmen Methner; Sergiy M Nadtochiy; Angela Logan; Victoria R Pell; Shujing Ding; Andrew M James; Helena M Cochemé; Johannes Reinhold; Kathryn S Lilley; Linda Partridge; Ian M Fearnley; Alan J Robinson; Richard C Hartley; Robin A J Smith; Thomas Krieg; Paul S Brookes; Michael P Murphy
Journal:  Nat Med       Date:  2013-05-26       Impact factor: 53.440
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  64 in total

1.  Drp1 and Mitochondrial Autophagy Lend a Helping Hand in Adaptation to Pressure Overload.

Authors:  Shigeki Miyamoto; Joan Heller Brown
Journal:  Circulation       Date:  2016-02-25       Impact factor: 29.690

Review 2.  Ischemia/Reperfusion.

Authors:  Theodore Kalogeris; Christopher P Baines; Maike Krenz; Ronald J Korthuis
Journal:  Compr Physiol       Date:  2016-12-06       Impact factor: 9.090

Review 3.  Targeting Oxidative Stress Using Nanoparticles as a Theranostic Strategy for Cardiovascular Diseases.

Authors:  Kye S Kim; Chul Gyu Song; Peter M Kang
Journal:  Antioxid Redox Signal       Date:  2018-01-30       Impact factor: 8.401

Review 4.  Post-translational modifications in mitochondria: protein signaling in the powerhouse.

Authors:  Amanda R Stram; R Mark Payne
Journal:  Cell Mol Life Sci       Date:  2016-05-27       Impact factor: 9.261

5.  Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation.

Authors:  Nir Qvit; Opher S Kornfeld
Journal:  J Vis Exp       Date:  2016-01-26       Impact factor: 1.355

Review 6.  High-Density Lipoprotein Regulation of Mitochondrial Function.

Authors:  C Roger White; Geeta Datta; Samantha Giordano
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622

7.  Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

Authors:  Nir Qvit; Opher S Kornfeld; Daria Mochly-Rosen
Journal:  Angew Chem Int Ed Engl       Date:  2016-11-17       Impact factor: 15.336

Review 8.  The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.

Authors:  Amit U Joshi; Opher S Kornfeld; Daria Mochly-Rosen
Journal:  Cell Calcium       Date:  2016-05-07       Impact factor: 6.817

9.  Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.

Authors:  Bereketeab Haileselassie; Riddhita Mukherjee; Amit U Joshi; Brooke A Napier; Liliana M Massis; Nicolai Patrick Ostberg; Bruno B Queliconi; Denise Monack; Daniel Bernstein; Daria Mochly-Rosen
Journal:  J Mol Cell Cardiol       Date:  2019-04-11       Impact factor: 5.000

Review 10.  Autophagy and cardiac aging.

Authors:  Shigeki Miyamoto
Journal:  Cell Death Differ       Date:  2019-01-28       Impact factor: 15.828
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