Literature DB >> 25999027

Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei.

Richard McCulloch1, Mark C Field2.   

Abstract

Antigenic variation is central to the virulence of African trypanosomes, where the VSG coat is used to evade the host immune system. Recent advances in technology have now allowed more secrets of this system to emerge, with the surprising insight that a broad repertoire of VSGs is rapidly expressed. This has major implications for how the parasite must evade the host immune response.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Trypanosoma brucei; VSG; antigenic variation; immune evasion; recombination

Mesh：

Substances：

Year:  2015        PMID： 25999027      PMCID： PMC7612307          DOI： 10.1016/j.pt.2015.05.001

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  10 in total

1.  Probabilistic order in antigenic variation of Trypanosoma brucei.

Authors:  Liam J Morrison; Phelix Majiwa; Andrew F Read; J David Barry
Journal:  Int J Parasitol       Date:  2005-08       Impact factor: 3.981

2.  The in vivo dynamics of antigenic variation in Trypanosoma brucei.

Authors:  Monica R Mugnier; George A M Cross; F Nina Papavasiliou
Journal:  Science       Date:  2015-03-27       Impact factor: 47.728

Review 3.  Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act.

Authors:  Paula MacGregor; Balazs Szöőr; Nicholas J Savill; Keith R Matthews
Journal:  Nat Rev Microbiol       Date:  2012-04-30       Impact factor: 60.633

4.  Critical interplay between parasite differentiation, host immunity, and antigenic variation in trypanosome infections.

Authors:  E Gjini; D T Haydon; J D Barry; C A Cobbold
Journal:  Am Nat       Date:  2010-10       Impact factor: 3.926

Review 5.  'Nothing is permanent but change'- antigenic variation in persistent bacterial pathogens.

Authors:  Guy H Palmer; Troy Bankhead; Sheila A Lukehart
Journal:  Cell Microbiol       Date:  2009-08-25       Impact factor: 3.715

6.  Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure.

Authors:  Lucio Marcello; J David Barry
Journal:  Genome Res       Date:  2007-07-25       Impact factor: 9.043

Review 7.  Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens.

Authors:  Kirk W Deitsch; Sheila A Lukehart; James R Stringer
Journal:  Nat Rev Microbiol       Date:  2009-06-08       Impact factor: 60.633

8.  Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.

Authors:  James P J Hall; Huanhuan Wang; J David Barry
Journal:  PLoS Pathog       Date:  2013-07-11       Impact factor: 6.823

9.  DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes.

Authors:  Lucy Glover; Sam Alsford; David Horn
Journal:  PLoS Pathog       Date:  2013-03-28       Impact factor: 6.823

Review 10.  Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.

Authors:  Lucy Glover; Sebastian Hutchinson; Sam Alsford; Richard McCulloch; Mark C Field; David Horn
Journal:  Cell Microbiol       Date:  2013-10-10       Impact factor: 3.715
  10 in total
  8 in total

Review 1.  All For One and One For All on the Tick-Host Battlefield.

Authors:  Jindřich Chmelař; Jan Kotál; Jan Kopecký; Joao H F Pedra; Michail Kotsyfakis
Journal:  Trends Parasitol       Date:  2016-01-30

Review 2.  Vertebrate Adaptive Immunity-Comparative Insights from a Teleost Model.

Authors:  Harry W Dickerson; Robert Craig Findly
Journal:  Front Immunol       Date:  2017-10-26       Impact factor: 7.561

Review 3.  Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes.

Authors:  Igor Cestari; Ken Stuart
Journal:  Curr Genomics       Date:  2018-02       Impact factor: 2.236

Review 4.  Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

Authors:  Rebecca Devlin; Catarina A Marques; Richard McCulloch
Journal:  Curr Genet       Date:  2016-11-07       Impact factor: 3.886

5.  RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse.

Authors:  Fernando Fernandez-Cortes; Tiago D Serafim; Jonathan M Wilkes; Nathaniel G Jones; Ryan Ritchie; Richard McCulloch; Jeremy C Mottram
Journal:  Sci Rep       Date:  2017-07-21       Impact factor: 4.379

Review 6.  Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes.

Authors:  Marcelo Santos da Silva; Galadriel A Hovel-Miner; Emma M Briggs; Maria Carolina Elias; Richard McCulloch
Journal:  PLoS Pathog       Date:  2018-11-15       Impact factor: 6.823

7.  Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle.

Authors:  Enock Matovu; Annah Kitibwa; Albert Picado; Sylvain Biéler; Paul R Bessell; Joseph Mathu Ndung'u
Journal:  Parasit Vectors       Date:  2017-11-03       Impact factor: 3.876

8.  Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens.

Authors:  Jennifer Ann Black; Kathryn Crouch; Leandro Lemgruber; Craig Lapsley; Nicholas Dickens; Luiz R O Tosi; Jeremy C Mottram; Richard McCulloch
Journal:  Cell Rep       Date:  2020-01-21       Impact factor: 9.423
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.