AIM: We evaluated whether the concurrent β-blocker use in early breast cancer patients influenced the outcome in terms of preventing tumor recurrence after adjuvant chemotherapy. METHODS: We retrospectively reviewed the medical records of 610 patients with breast cancer. Thereafter, we compared overall disease-free survival (DFS) between β-blocker users and nonusers. RESULTS: Those not receiving β-blockers had a relatively longer mean DFS (10.8 vs. 9.7 years), although the difference did not reach statistical significance (p = 0.651). When the survival analysis was adjusted for age, tumor stage, hormone receptor status and HER2 status, the results remained unaltered, suggesting that β-blocker use did not significantly improve overall DFS (HR, 0.849; 95% CI, 0.537-1.343; p = 0.485). CONCLUSION: Our findings failed to confirm previous results indicating a potential antitumor effect of β-blockers.
AIM: We evaluated whether the concurrent β-blocker use in early breast cancerpatients influenced the outcome in terms of preventing tumor recurrence after adjuvant chemotherapy. METHODS: We retrospectively reviewed the medical records of 610 patients with breast cancer. Thereafter, we compared overall disease-free survival (DFS) between β-blocker users and nonusers. RESULTS: Those not receiving β-blockers had a relatively longer mean DFS (10.8 vs. 9.7 years), although the difference did not reach statistical significance (p = 0.651). When the survival analysis was adjusted for age, tumor stage, hormone receptor status and HER2 status, the results remained unaltered, suggesting that β-blocker use did not significantly improve overall DFS (HR, 0.849; 95% CI, 0.537-1.343; p = 0.485). CONCLUSION: Our findings failed to confirm previous results indicating a potential antitumor effect of β-blockers.
Authors: Yuxiu Xie; Men Wang; Peng Xu; Yujiao Deng; Yi Zheng; Si Yang; Ying Wu; Zhen Zhai; Dai Zhang; Na Li; Nan Wang; Jing Cheng; Zhijun Dai Journal: Front Pharmacol Date: 2021-05-13 Impact factor: 5.810
Authors: Ondrej Fiala; Pavel Ostasov; Ondrej Sorejs; Vaclav Liska; Tomas Buchler; Alexandr Poprach; Jindrich Finek Journal: Cancers (Basel) Date: 2019-11-25 Impact factor: 6.639