Literature DB >> 25998695

Intestinal farnesoid X receptor puts a fresh coat of wax on fatty liver.

Iina Tuominen1, Simon W Beaven1,2.   

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Year:  2015        PMID： 25998695      PMCID： PMC4523235          DOI： 10.1002/hep.27910

Source DB:  PubMed          Journal:  Hepatology        ISSN： 0270-9139            Impact factor:   17.425


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  8 in total

1.  Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal.

Authors:  Johannes Schmitt; Bo Kong; Grace L Guo; Andreas Geier; Bruno Stieger; Oliver Tschopp; Simon M Schultze; Monika Rau; Achim Weber; Beat Müllhaupt
Journal:  Liver Int       Date:  2014-02-07       Impact factor: 5.828

2.  Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.

Authors:  Brent A Neuschwander-Tetri; Rohit Loomba; Arun J Sanyal; Joel E Lavine; Mark L Van Natta; Manal F Abdelmalek; Naga Chalasani; Srinivasan Dasarathy; Anna Mae Diehl; Bilal Hameed; Kris V Kowdley; Arthur McCullough; Norah Terrault; Jeanne M Clark; James Tonascia; Elizabeth M Brunt; David E Kleiner; Edward Doo
Journal:  Lancet       Date:  2014-11-07       Impact factor: 79.321

3.  Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

Authors:  Takeshi Inagaki; Mihwa Choi; Antonio Moschetta; Li Peng; Carolyn L Cummins; Jeffrey G McDonald; Guizhen Luo; Stacey A Jones; Bryan Goodwin; James A Richardson; Robert D Gerard; Joyce J Repa; David J Mangelsdorf; Steven A Kliewer
Journal:  Cell Metab       Date:  2005-10       Impact factor: 27.287

4.  Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila.

Authors:  I Y Dobrosotskaya; A C Seegmiller; M S Brown; J L Goldstein; R B Rawson
Journal:  Science       Date:  2002-05-03       Impact factor: 47.728

5.  Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.

Authors:  Changtao Jiang; Cen Xie; Fei Li; Limin Zhang; Robert G Nichols; Kristopher W Krausz; Jingwei Cai; Yunpeng Qi; Zhong-Ze Fang; Shogo Takahashi; Naoki Tanaka; Dhimant Desai; Shantu G Amin; Istvan Albert; Andrew D Patterson; Frank J Gonzalez
Journal:  J Clin Invest       Date:  2014-12-15       Impact factor: 14.808

6.  Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

Authors:  Fei Li; Changtao Jiang; Kristopher W Krausz; Yunfei Li; Istvan Albert; Haiping Hao; Kristin M Fabre; James B Mitchell; Andrew D Patterson; Frank J Gonzalez
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

7.  Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Authors:  Sungsoon Fang; Jae Myoung Suh; Shannon M Reilly; Elizabeth Yu; Olivia Osborn; Denise Lackey; Eiji Yoshihara; Alessia Perino; Sandra Jacinto; Yelizaveta Lukasheva; Annette R Atkins; Alexander Khvat; Bernd Schnabl; Ruth T Yu; David A Brenner; Sally Coulter; Christopher Liddle; Kristina Schoonjans; Jerrold M Olefsky; Alan R Saltiel; Michael Downes; Ronald M Evans
Journal:  Nat Med       Date:  2015-01-05       Impact factor: 53.440

8.  FXR is a molecular target for the effects of vertical sleeve gastrectomy.

Authors:  Karen K Ryan; Valentina Tremaroli; Christoffer Clemmensen; Petia Kovatcheva-Datchary; Andriy Myronovych; Rebekah Karns; Hilary E Wilson-Pérez; Darleen A Sandoval; Rohit Kohli; Fredrik Bäckhed; Randy J Seeley
Journal:  Nature       Date:  2014-03-26       Impact factor: 49.962
  8 in total
  4 in total

Review 1.  The role of the gut microbiota in NAFLD.

Authors:  Christopher Leung; Leni Rivera; John B Furness; Peter W Angus
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2016-06-08       Impact factor: 46.802

2.  Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease.

Authors:  Brett M McGettigan; Rachel H McMahan; Yuhuan Luo; Xiaoxin X Wang; David J Orlicky; Cara Porsche; Moshe Levi; Hugo R Rosen
Journal:  J Biol Chem       Date:  2016-09-07       Impact factor: 5.157

3.  Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism.

Authors:  Limin Zhang; Cen Xie; Robert G Nichols; Siu H J Chan; Changtao Jiang; Ruixin Hao; Philip B Smith; Jingwei Cai; Margaret N Simons; Emmanuel Hatzakis; Costas D Maranas; Frank J Gonzalez; Andrew D Patterson
Journal:  mSystems       Date:  2016-10-11       Impact factor: 6.496

4.  Changes of farnesoid X receptor and Takeda G-protein coupled receptor 5 following biliary tract external drainage in hemorrhagic shock.

Authors:  Lu Wang; Huai-Wu He; Xiang Zhou; Yun Long
Journal:  Exp Ther Med       Date:  2021-12-21       Impact factor: 2.447
  4 in total

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