Dina Lo Giudice1, Kate Smith2, Stephen Fenner3, Zoë Hyde4, David Atkinson5, Linda Skeaf2, Roslyn Malay2, Leon Flicker6. 1. Aged Care, Melbourne Health, Melbourne, Australia; WA Centre for Health & Ageing, Centre for Medical Research, Perth, Australia. Electronic address: dina.logiudice@mhorg.au. 2. WA Centre for Health & Ageing, Centre for Medical Research, Perth, Australia. 3. Department of Psychiatry, Royal Perth Hospital, Perth, Australia. 4. WA Centre for Health & Ageing, Centre for Medical Research, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia. 5. Rural Clinical School of WA, University of Western Australia, Perth, Australia; Kimberley Aboriginal Medical Services, Broome, Australia. 6. WA Centre for Health & Ageing, Centre for Medical Research, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Geriatric Medicine, Royal Perth Hospital, Perth, Australia.
Abstract
INTRODUCTION: Aboriginal Australians are reported to develop dementia earlier than the general population. The causes remain unknown. METHODS: This was a longitudinal study of 363 participants aged ≥45 years. Consensus diagnoses were established for cognitive impairment or dementia. RESULTS: At follow-up, 189 people (mean ± standard deviation age, 65.4 ± 10.3 years) participated, as 109 (30%) had died and 65 (18%) were unavailable. The incidence of cognitive impairment or dementia was 52.6 (95% confidence interval 33.9, 81.5) per 1000 person-years (380.3 total person-years) and for dementia was 21.0 (10.5, 42.1) per 1000 person-years (380.3 person-years total) over the age 60 years. Longitudinal risk factors associated with a decline from normal cognition to impairment were age and head injury. Other associations with cognitive decline were stroke, head injury, nonaspirin analgesics, lower BMI, and higher systolic BP. DISCUSSION: Dementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.
INTRODUCTION: Aboriginal Australians are reported to develop dementia earlier than the general population. The causes remain unknown. METHODS: This was a longitudinal study of 363 participants aged ≥45 years. Consensus diagnoses were established for cognitive impairment or dementia. RESULTS: At follow-up, 189 people (mean ± standard deviation age, 65.4 ± 10.3 years) participated, as 109 (30%) had died and 65 (18%) were unavailable. The incidence of cognitive impairment or dementia was 52.6 (95% confidence interval 33.9, 81.5) per 1000 person-years (380.3 total person-years) and for dementia was 21.0 (10.5, 42.1) per 1000 person-years (380.3 person-years total) over the age 60 years. Longitudinal risk factors associated with a decline from normal cognition to impairment were age and head injury. Other associations with cognitive decline were stroke, head injury, nonaspirin analgesics, lower BMI, and higher systolic BP. DISCUSSION: Dementia incidence in Aboriginal Australians is among the highest in the world, and is associated with age and head injury.
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Authors: Ana W Capuano; Robert S Wilson; Sue E Leurgans; Jeffrey D Dawson; David A Bennett; Donald Hedeker Journal: Stat Methods Med Res Date: 2016-04-28 Impact factor: 3.021
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Authors: Kylie Radford; Louise M Lavrencic; Kim Delbaere; Brian Draper; Robert Cumming; Gail Daylight; Holly A Mack; Simon Chalkley; Hayley Bennett; Gail Garvey; Thi Yen Hill; Danielle Lasschuit; Gerald A Broe Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
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