Julia Jacobs1, Christina Vogt1, Pierre LeVan2, Rina Zelmann3, Jean Gotman3, Katsuhiro Kobayashi4. 1. Department of Neuropediatrics and Muscular Diseases, University Medical Center Freiburg, Germany. 2. Medical Physics, University Medical Center Freiburg, Germany. 3. Montreal Neurological Institute, McGill University, Canada. 4. Department of Child Neurology, Okayama University Hospital, Kita-ku, Okayama, Japan.
Abstract
OBJECTIVE: Interictal high-frequency oscillations (HFOs, 80-500Hz) can predict the seizure onset zone (SOZ), but visual detection of HFOs is time consuming. Time-frequency analysis can reveal large high-frequency (HF) power changes (80-500Hz) associated with inter-ictal spikes. The present study determines how well the rate of HFOs and spike-related HF power changes were co-localized with SOZ. METHODS: We analyzed 583 channels (68 in the SOZ) sampled from 14 patients who underwent intracranial EEG recording. We determined if the rate of visually-marked HFOs and spike-related HF power changes differed between SOZ and non-SOZ. RESULTS: Significantly higher rates of HFOs were found in SOZ. The degree of spike-related HF power augmentation failed to differ between SOZ and non-SOZ, whereas that of post-spike HF power attenuation was significantly more severe in SOZ compared to in non-SOZ. Regions showing HFOs and large spike-related HF-changes showed a partial overlap in distribution in 7/14 patients. CONCLUSIONS: Strong HF augmentation during spikes and high HFO rates occurred over different brain locations. The rate of HFOs showed the best performance in identifying SOZ. Post-spike HF power attenuation may represent increased inhibition in these channels and should be investigated further. SIGNIFICANCE: Strong HF power changes during spikes and HFOs per se seem to reflect distinct phenomena.
OBJECTIVE: Interictal high-frequency oscillations (HFOs, 80-500Hz) can predict the seizure onset zone (SOZ), but visual detection of HFOs is time consuming. Time-frequency analysis can reveal large high-frequency (HF) power changes (80-500Hz) associated with inter-ictal spikes. The present study determines how well the rate of HFOs and spike-related HF power changes were co-localized with SOZ. METHODS: We analyzed 583 channels (68 in the SOZ) sampled from 14 patients who underwent intracranial EEG recording. We determined if the rate of visually-marked HFOs and spike-related HF power changes differed between SOZ and non-SOZ. RESULTS: Significantly higher rates of HFOs were found in SOZ. The degree of spike-related HF power augmentation failed to differ between SOZ and non-SOZ, whereas that of post-spike HF power attenuation was significantly more severe in SOZ compared to in non-SOZ. Regions showing HFOs and large spike-related HF-changes showed a partial overlap in distribution in 7/14 patients. CONCLUSIONS: Strong HF augmentation during spikes and high HFO rates occurred over different brain locations. The rate of HFOs showed the best performance in identifying SOZ. Post-spike HF power attenuation may represent increased inhibition in these channels and should be investigated further. SIGNIFICANCE: Strong HF power changes during spikes and HFOs per se seem to reflect distinct phenomena.
Authors: Birgit Frauscher; Fabrice Bartolomei; Katsuhiro Kobayashi; Jan Cimbalnik; Maryse A van 't Klooster; Stefan Rampp; Hiroshi Otsubo; Yvonne Höller; Joyce Y Wu; Eishi Asano; Jerome Engel; Philippe Kahane; Julia Jacobs; Jean Gotman Journal: Epilepsia Date: 2017-06-30 Impact factor: 5.864
Authors: Kathryn A Davis; Seth P Devries; Abba Krieger; Temenuzhka Mihaylova; Daniela Minecan; Brian Litt; Joost B Wagenaar; William C Stacey Journal: Clin Neurophysiol Date: 2017-11-16 Impact factor: 3.708
Authors: Jan Schönberger; Anja Knopf; Kerstin Alexandra Klotz; Matthias Dümpelmann; Andreas Schulze-Bonhage; Julia Jacobs Journal: Brain Sci Date: 2021-04-24