| Literature DB >> 25997795 |
Abstract
The gap between prebiotic chemistry and the RNA origin of life lies in the nature of the pre-ribonucleotides that initiated replication-like activity. The present paper illustrates how the constraints for self-catalytic synthesis of the building blocks point to ionic pairing of the first pre-ribonucleotides and point to a central role for nicotinate.Entities:
Keywords: ionic pairing; phosphoribosyl-aspartate; pre-ribonucleotide; reduced carbon chemistry; self-catalytic synthesis
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Year: 2015 PMID： 25997795 DOI： 10.1016/j.jtbi.2015.05.013
Source DB: PubMed Journal: J Theor Biol ISSN： 0022-5193 Impact factor: 2.691