Mohamed H Emara1, Soha A Elhawari1, Salem Yousef2, Mohamed I Radwan1, Hesham R Abdel-Aziz3. 1. Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt. 2. Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. 3. Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.
Abstract
BACKGROUND: There is growing evidence from preclinical and clinical studies that emphasizes the efficacy of probiotics in the management of Helicobacter (H) pylori infection; it increased the eradication rate, improved patient clinical manifestations and lowered treatment associated side effects. AIM: In this review we documented the potential ability of probiotics to ameliorate H. pylori induced histological features. MATERIALS AND METHODS: We searched the available literature for full length articles focusing the role of probiotics on H. pylori induced gastritis from histologic perspectives. RESULTS: Probiotics lowered H. pylori density at the luminal side of epithelium, improved histological inflammatory and activity scores both in the gastric corpus and antrum. This effect persists for long period of time after discontinuation of probiotic supplementation and this is probably through an immune mechanism. CONCLUSIONS: The current evidence support the promising role of probiotics in improving H. pylori induced histopathological features both in gastric antrum and corpus and for long periods of time. Because increased density of H. pylori on the gastric mucosa is linked to more severe gastritis and increased incidence of peptic ulcers, we can infer that a reduction of the density might help to decrease the risk of developing pathologies, probably the progression toward atrophic gastritis and gastric adenocarcinoma. These effects together with improving the H. pylori eradication rates and amelioration of treatment related side effects might open the door for probiotics to be added to H. pylori eradication regimens.
BACKGROUND: There is growing evidence from preclinical and clinical studies that emphasizes the efficacy of probiotics in the management of Helicobacter (H) pyloriinfection; it increased the eradication rate, improved patient clinical manifestations and lowered treatment associated side effects. AIM: In this review we documented the potential ability of probiotics to ameliorate H. pylori induced histological features. MATERIALS AND METHODS: We searched the available literature for full length articles focusing the role of probiotics on H. pylori induced gastritis from histologic perspectives. RESULTS: Probiotics lowered H. pylori density at the luminal side of epithelium, improved histological inflammatory and activity scores both in the gastric corpus and antrum. This effect persists for long period of time after discontinuation of probiotic supplementation and this is probably through an immune mechanism. CONCLUSIONS: The current evidence support the promising role of probiotics in improving H. pylori induced histopathological features both in gastric antrum and corpus and for long periods of time. Because increased density of H. pylori on the gastric mucosa is linked to more severe gastritis and increased incidence of peptic ulcers, we can infer that a reduction of the density might help to decrease the risk of developing pathologies, probably the progression toward atrophic gastritis and gastric adenocarcinoma. These effects together with improving the H. pylori eradication rates and amelioration of treatment related side effects might open the door for probiotics to be added to H. pylori eradication regimens.
Authors: Peter A Bron; Michiel Kleerebezem; Robert-Jan Brummer; Patrice D Cani; Annick Mercenier; Thomas T MacDonald; Clara L Garcia-Ródenas; Jerry M Wells Journal: Br J Nutr Date: 2017-01 Impact factor: 3.718
Authors: Jin Young Yoon; Jae Myung Cha; Seong Soo Hong; Hyung Kyung Kim; Min Seob Kwak; Jung Won Jeon; Hyun Phil Shin Journal: Medicine (Baltimore) Date: 2019-08 Impact factor: 1.817
Authors: Paula Roszczenko-Jasińska; Marta Ilona Wojtyś; Elżbieta K Jagusztyn-Krynicka Journal: Appl Microbiol Biotechnol Date: 2020-10-14 Impact factor: 4.813