Literature DB >> 25996906

Bi(OTf)3-Catalyzed Multicomponent α-Amidoalkylation Reactions.

Angelika E Schneider1, Georg Manolikakes1.   

Abstract

A bismuth(III) triflate catalyzed three-component synthesis of α-substituted amides starting from amides, aldehydes, and (hetero)arenes is reported. The reaction has a broad substrate scope, encompassing formaldehyde as well as aryl and alkyl aldehydes. Low catalyst loadings are required, and water is formed as the only side product. The scope and limitation of this method will be discussed.

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Year:  2015        PMID： 25996906     DOI： 10.1021/acs.joc.5b00662

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  1-Imidoalkylphosphonium salts with modulated Cα-P+ bond strength: synthesis and application as new active α-imidoalkylating agents.

Authors:  Jakub Adamek; Roman Mazurkiewicz; Anna Węgrzyk; Karol Erfurt
Journal:  Beilstein J Org Chem       Date:  2017-07-24       Impact factor: 2.883

Review 2.  Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis.

Authors:  Brenno A D Neto; Rafael O Rocha; Marcelo O Rodrigues
Journal:  Molecules       Date:  2021-12-27       Impact factor: 4.411

Review 3.  1-Aminoalkylphosphonium Derivatives: Smart Synthetic Equivalents of N-Acyliminium-Type Cations, and Maybe Something More: A Review.

Authors:  Jakub Adamek; Mirosława Grymel; Anna Kuźnik; Agnieszka Październiok-Holewa
Journal:  Molecules       Date:  2022-02-26       Impact factor: 4.411

4.  1-(N-Acylamino)alkyltriarylphosphonium Salts with Weakened Cα-P⁺ Bond Strength-Synthetic Applications.

Authors:  Jakub Adamek; Anna Węgrzyk; Justyna Kończewicz; Krzysztof Walczak; Karol Erfurt
Journal:  Molecules       Date:  2018-09-25       Impact factor: 4.411
  4 in total

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