Andrea Romano1, Riccardo Cornia2, Marta Moraschi1, Alessandro Bozzao3, Laura Chiacchiararelli4, Valeria Coppola3, Cristina Iani5, Giacomo Stella2, Giorgio Albertini6, Alberto Pierallini7. 1. San Raffaele Foundation, Rehabilitation Facility, Merit Project RBNE08E8CZ. 2. University of Modena and Reggio Emilia, Departments of Biomedical, Metabolic and Neurosciences. 3. University Sapienza, NESMOS, Department of Neuroradiology, S.Andrea Hospital. 4. University Sapienza, Department of Medical Phisics, S.Andrea Hospital. 5. University of Modena and Reggio Emilia, Department of Communication and Economy. 6. IRCSS San Raffaele Pisana, Department of Pediatry. 7. IRCSS San Raffaele Pisana, Department of Radiology.
Abstract
BACKGROUND AND PURPOSE: The aim of this study was to investigate the characteristic pattern of age-related cortical thinning in patients with Down Syndrome (DS), as assessed by MRI and automatic cortical thickness measurements. METHODS: Ninety-one non-demented subjects with DS (range 11-53 years) were examined using a 1.5 T scanner. MRI-based quantification of cortical thickness was performed using FreeSurfer software package., The Pearson product-moment correlation coefficient between age and mean cortical thickness was evaluated for all subjects participating in the study. RESULTS: A significant negative correlation between cortical thickness and age was found bilaterally in the frontal, temporal, parietal and cingulate gyrus. Specific investigation of cerebral lobes showed a more evident involvement of the frontal one, compared to others. Moreover, the age related reduction of cortical thickness appeared to be more significant and rapid in patients between 20 and 30 years of age. CONCLUSIONS: Our findings showed that Down Syndrome subjects are affected by a diffuse cortical thinning. The involvement of cortical structures can be observed at an earlier age than previous studies have reported.
BACKGROUND AND PURPOSE: The aim of this study was to investigate the characteristic pattern of age-related cortical thinning in patients with Down Syndrome (DS), as assessed by MRI and automatic cortical thickness measurements. METHODS: Ninety-one non-demented subjects with DS (range 11-53 years) were examined using a 1.5 T scanner. MRI-based quantification of cortical thickness was performed using FreeSurfer software package., The Pearson product-moment correlation coefficient between age and mean cortical thickness was evaluated for all subjects participating in the study. RESULTS: A significant negative correlation between cortical thickness and age was found bilaterally in the frontal, temporal, parietal and cingulate gyrus. Specific investigation of cerebral lobes showed a more evident involvement of the frontal one, compared to others. Moreover, the age related reduction of cortical thickness appeared to be more significant and rapid in patients between 20 and 30 years of age. CONCLUSIONS: Our findings showed that Down Syndrome subjects are affected by a diffuse cortical thinning. The involvement of cortical structures can be observed at an earlier age than previous studies have reported.
Authors: Andrea Romano; Marta Moraschi; Riccardo Cornia; Alessandro Bozzao; Maria Camilla Rossi-Espagnet; Federico Giove; Giorgio Albertini; Alberto Pierallini Journal: Neuroradiology Date: 2018-09-27 Impact factor: 2.804
Authors: James H Cole; Tiina Annus; Liam R Wilson; Ridhaa Remtulla; Young T Hong; Tim D Fryer; Julio Acosta-Cabronero; Arturo Cardenas-Blanco; Robert Smith; David K Menon; Shahid H Zaman; Peter J Nestor; Anthony J Holland Journal: Neurobiol Aging Date: 2017-04-18 Impact factor: 4.673
Authors: A-L Lin; D Powell; A Caban-Holt; G Jicha; W Robertson; B T Gold; R Davis; E Abner; D M Wilcock; F A Schmitt; E Head Journal: Neuroimage Clin Date: 2016-06-02 Impact factor: 4.881
Authors: Arezoo Rezazadeh; Eduard Bercovici; Tim-Rasmus Kiehl; Eva W Chow; Timo Krings; Anne S Bassett; Danielle M Andrade Journal: Ann Clin Transl Neurol Date: 2018-09-23 Impact factor: 4.511