Literature DB >> 25996132

The challenge of understanding the brain: where we stand in 2015.

John Lisman1.   

Abstract

Starting with the work of Cajal more than 100 years ago, neuroscience has sought to understand how the cells of the brain give rise to cognitive functions. How far has neuroscience progressed in this endeavor? This Perspective assesses progress in elucidating five basic brain processes: visual recognition, long-term memory, short-term memory, action selection, and motor control. Each of these processes entails several levels of analysis: the behavioral properties, the underlying computational algorithm, and the cellular/network mechanisms that implement that algorithm. At this juncture, while many questions remain unanswered, achievements in several areas of research have made it possible to relate specific properties of brain networks to cognitive functions. What has been learned reveals, at least in rough outline, how cognitive processes can be an emergent property of neurons and their connections.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID: 25996132      PMCID: PMC4441769          DOI: 10.1016/j.neuron.2015.03.032

Source DB:  PubMed          Journal:  Neuron        ISSN: 0896-6273            Impact factor:   17.173


  243 in total

1.  A role for NMDA-receptor channels in working memory.

Authors:  J E Lisman; J M Fellous; X J Wang
Journal:  Nat Neurosci       Date:  1998-08       Impact factor: 24.884

2.  The time course of visual processing: from early perception to decision-making.

Authors:  R VanRullen; S J Thorpe
Journal:  J Cogn Neurosci       Date:  2001-05-15       Impact factor: 3.225

3.  Imagery neurons in the human brain.

Authors:  G Kreiman; C Koch; I Fried
Journal:  Nature       Date:  2000-11-16       Impact factor: 49.962

4.  Temporal association in asymmetric neural networks.

Authors: 
Journal:  Phys Rev Lett       Date:  1986-12-01       Impact factor: 9.161

Review 5.  A neural substrate of prediction and reward.

Authors:  W Schultz; P Dayan; P R Montague
Journal:  Science       Date:  1997-03-14       Impact factor: 47.728

6.  Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex.

Authors:  Kyle S Smith; Arti Virkud; Karl Deisseroth; Ann M Graybiel
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-29       Impact factor: 11.205

7.  A goal-directed spatial navigation model using forward trajectory planning based on grid cells.

Authors:  Uğur M Erdem; Michael Hasselmo
Journal:  Eur J Neurosci       Date:  2012-03-07       Impact factor: 3.386

Review 8.  Distributed modular architectures linking basal ganglia, cerebellum, and cerebral cortex: their role in planning and controlling action.

Authors:  J C Houk; S P Wise
Journal:  Cereb Cortex       Date:  1995 Mar-Apr       Impact factor: 5.357

9.  Robust conjunctive item-place coding by hippocampal neurons parallels learning what happens where.

Authors:  Robert W Komorowski; Joseph R Manns; Howard Eichenbaum
Journal:  J Neurosci       Date:  2009-08-05       Impact factor: 6.167

10.  Schemas and memory consolidation.

Authors:  Dorothy Tse; Rosamund F Langston; Masaki Kakeyama; Ingrid Bethus; Patrick A Spooner; Emma R Wood; Menno P Witter; Richard G M Morris
Journal:  Science       Date:  2007-04-06       Impact factor: 47.728

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  20 in total

1.  Proximal-distal differences in movement smoothness reflect differences in biomechanics.

Authors:  Layne H Salmond; Andrew D Davidson; Steven K Charles
Journal:  J Neurophysiol       Date:  2016-12-21       Impact factor: 2.714

Review 2.  Top-down models in biology: explanation and control of complex living systems above the molecular level.

Authors:  Giovanni Pezzulo; Michael Levin
Journal:  J R Soc Interface       Date:  2016-11       Impact factor: 4.118

3.  The State of the NIH BRAIN Initiative.

Authors:  Walter Koroshetz; Joshua Gordon; Amy Adams; Andrea Beckel-Mitchener; James Churchill; Gregory Farber; Michelle Freund; Jim Gnadt; Nina S Hsu; Nicholas Langhals; Sarah Lisanby; Guoying Liu; Grace C Y Peng; Khara Ramos; Michael Steinmetz; Edmund Talley; Samantha White
Journal:  J Neurosci       Date:  2018-06-19       Impact factor: 6.167

Review 4.  Computational principles of memory.

Authors:  Rishidev Chaudhuri; Ila Fiete
Journal:  Nat Neurosci       Date:  2016-03       Impact factor: 24.884

5.  High-yield in vitro recordings from neurons functionally characterized in vivo.

Authors:  Simon Weiler; Joel Bauer; Mark Hübener; Tobias Bonhoeffer; Tobias Rose; Volker Scheuss
Journal:  Nat Protoc       Date:  2018-05-10       Impact factor: 13.491

6.  Mental simulation of routes during navigation involves adaptive temporal compression.

Authors:  Aiden E G F Arnold; Giuseppe Iaria; Arne D Ekstrom
Journal:  Cognition       Date:  2016-08-29

7.  Handling Metadata in a Neurophysiology Laboratory.

Authors:  Lyuba Zehl; Florent Jaillet; Adrian Stoewer; Jan Grewe; Andrey Sobolev; Thomas Wachtler; Thomas G Brochier; Alexa Riehle; Michael Denker; Sonja Grün
Journal:  Front Neuroinform       Date:  2016-07-19       Impact factor: 4.081

8.  Systems Biology, Neuroimaging, Neuropsychology, Neuroconnectivity and Traumatic Brain Injury.

Authors:  Erin D Bigler
Journal:  Front Syst Neurosci       Date:  2016-08-09

9.  Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off.

Authors:  Verónica María Corrales-Carvajal; Aldo A Faisal; Carlos Ribeiro
Journal:  Elife       Date:  2016-10-22       Impact factor: 8.140

10.  Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium.

Authors:  P Devaraju; J Yu; D Eddins; M M Mellado-Lagarde; L R Earls; J J Westmoreland; G Quarato; D R Green; S S Zakharenko
Journal:  Mol Psychiatry       Date:  2016-05-17       Impact factor: 15.992

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