Bioanalytics in Quantitive (Bio)imaging/Mapping of Metallic Elements in Biological Samples.

The aim of this article is to describe selected analytical techniques and their applications in the quantitative mapping/(bio)imaging of metals in biological samples. This work presents the advantages and disadvantages as well as the appropriate methods of scope for research. Distribution of metals in biological samples is currently one of the most important issues in physiology, toxicology, pharmacology, and other disciplines where functional information about the distribution of metals is essential. This issue is a subject of research in (bio)imaging/mapping studies, which use a variety of analytical techniques for the identification and determination of metallic elements. Increased interest in analytical techniques enabling the (bio)imaging of metals in a variety of biological material has been observed more recently. Measuring the distribution of trace metals in tissues after a drug dose or ingestion of poison-containing metals allows for the studying of pathomechanisms and the pathophysiology of various diseases and disorders related to the management of metals in human and animal systems.