| Literature DB >> 25994955 |
Carmen De Miguel1, David M Pollock2, Jennifer S Pollock1.
Abstract
The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.Entities:
Keywords: apoptosis; endothelin-1; renal injury
Mesh:
Substances:
Year: 2015 PMID: 25994955 PMCID: PMC4666951 DOI: 10.1152/ajpregu.00142.2015
Source DB: PubMed Journal: Am J Physiol Regul Integr Comp Physiol ISSN: 0363-6119 Impact factor: 3.619