Liangfu Zhu1, Qiuji Shao1, Tianxiao Li1, Jeffrey L Saver2, Li Li1, Dujuan Li1, Wenli Zhao1, Weijian Jiang3. 1. Cerebrovascular Center, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China. 2. The UCLA Stroke Center, University of California, Los Angeles, California, USA. 3. Department of Neurointervention, New Era Stroke Care and Research Center, Second Artillery General Hospital, Chinese People's Liberation Army, Beijing, China.
Abstract
OBJECTIVE: To evaluate the recanalization efficacy and safety of a novel stent retriever in a swine model of acute arterial occlusion. METHODS: The JRecan thrombectomy device, a stent retriever with a weaving stent design, was evaluated in 18 occluded cervicocerebral vessels of swine. The flow restoration effect immediately upon deployment, the reperfusion rate after retrieval, thromboembolic events, and complications were assessed. The histologic structure of the renal arteries after retriever passage was measured to further assess the safety of JRecan. RESULTS: Immediate flow restoration was achieved in 66.7% of occlusions (12/18). The reperfusion rate was 94.4% (two Thrombolysis in Cerebral Infarction (TICI) 2b and 15 TICI 3). Distal thromboembolic events did not occur. Microscopic examination of the arteries after retrieval showed mild degrees of endothelial loss in 96.6% (29/30), fibrin or platelet deposition in 53.3% (16/30), and disruption of the internal elastic lamina in 10% (3/30), without severe pathologic lesions. CONCLUSIONS: The JRecan is highly effective at clot removal with a favorable safety profile and merits further development as a stent retriever for the treatment of acute ischemic stroke. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
OBJECTIVE: To evaluate the recanalization efficacy and safety of a novel stent retriever in a swine model of acute arterial occlusion. METHODS: The JRecan thrombectomy device, a stent retriever with a weaving stent design, was evaluated in 18 occluded cervicocerebral vessels of swine. The flow restoration effect immediately upon deployment, the reperfusion rate after retrieval, thromboembolic events, and complications were assessed. The histologic structure of the renal arteries after retriever passage was measured to further assess the safety of JRecan. RESULTS: Immediate flow restoration was achieved in 66.7% of occlusions (12/18). The reperfusion rate was 94.4% (two Thrombolysis in Cerebral Infarction (TICI) 2b and 15 TICI 3). Distal thromboembolic events did not occur. Microscopic examination of the arteries after retrieval showed mild degrees of endothelial loss in 96.6% (29/30), fibrin or platelet deposition in 53.3% (16/30), and disruption of the internal elastic lamina in 10% (3/30), without severe pathologic lesions. CONCLUSIONS: The JRecan is highly effective at clot removal with a favorable safety profile and merits further development as a stent retriever for the treatment of acute ischemic stroke. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Authors: Andrea M Herrmann; Stephan Meckel; Matthew J Gounis; Leona Kringe; Edith Motschall; Christoph Mülling; Johannes Boltze Journal: J Cereb Blood Flow Metab Date: 2019-02-07 Impact factor: 6.200
Authors: Yang Liu; Mehdi Abbasi; Jorge L Arturo Larco; Ramanathan Kadirvel; David F Kallmes; Waleed Brinjikji; Luis Savastano Journal: J Neurointerv Surg Date: 2021-03-15 Impact factor: 8.572