Suzana N Machado1, Silvia Pereira2, Carlos Saboya3, Cláudia Saunders4, Andréa Ramalho5. 1. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro (INJC), School of Medicine at the Federal University of Rio de Janeiro, Universidade Federal do Rio de Janeiro/UFRJ (Federal University of Rio de Janeiro), Av. Carlos Chagas Filho Institute of Building 373. J Block, 2nd floor, room 26, Rio de Janeiro, RJ, 21941-590, Brazil. suzinunes@gmail.com. 2. Clínica Cirúrgica Carlos Saboya, NPqM/INJC/UFRJ, Universidade Federal do Rio de Janeiro/UFRJ (Federal University of Rio de Janeiro), Rio de Janeiro, RJ, Brazil. se.pereira@gmail.com. 3. Society of Bariatric and Metabolic Surgery, Clínica Cirúrgica Carlos Saboya, NPqM/INJC/UFRJ, Universidade Federal do Rio de Janeiro/UFRJ (Federal University of Rio de Janeiro), Rio de Janeiro, RJ, Brazil. cjsaboya@carlossaboya.com.br. 4. Department of Nutrition and Dietetics, Institute of Nutrition Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. claudiasaunders@nutricao.ufrj.br. 5. Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. aramalho.rj@gmail.com.
Abstract
OBJECTIVE: The objective of the present study is to evaluate the nutritional status of vitamin A through biochemical and functional indicators of pregnant women who underwent Roux-en-Y gastric bypass (RYGB) surgery compared to pregnant women who did not undergo this surgery. METHODS: The present study is a cross-sectional study of the analytical type with pregnant women paired by age and prepregnancy body mass index (BMI). Group 1 (G1) comprised 80 pregnant women without previous submission to RYGB and group 2 (G2) by 40 pregnant women who previously underwent this surgery. We used high-performance liquid chromatography with UV detector for quantification of retinol and β-carotene, and the functional evaluation of vitamin A deficiency (VAD) was performed through standardized interview validated for pregnant women. RESULTS: G1 mean age was 29.3 ± 5.3 and 30.8 ± 4.4 in G2. BMI mean prepregnancy found in G1 was 25.7 ± 3.2 and 26.8 ± 3.1 in G2, featuring overweight. Serum retinol and β-carotene means were significantly higher in G1 (1.8 ± 0.9; 87.4 ± 62.2) compared to G2 (0.99 ± 0.39; 22.7 ± 18.0), respectively (p < 0.001). Regarding the functional indicator for evaluation of VAD, approximately 75.0 % of pregnant women in G2 showed night blindness and 20.0 % in G1, and the percentage of pregnant women with this functional impairment was significantly higher in G2 compared to G1 with p < 0.001. CONCLUSION: Results show that pregnancy after RYGB can represent a high-risk situation for VAD. We recommend interdisciplinary monitoring added to the prenatal routine consultations and the conduction of studies addressed to the investigation of a safe and effective dose of oral supplementation of vitamin A to pregnant women undergoing RYGB.
OBJECTIVE: The objective of the present study is to evaluate the nutritional status of vitamin A through biochemical and functional indicators of pregnant women who underwent Roux-en-Y gastric bypass (RYGB) surgery compared to pregnant women who did not undergo this surgery. METHODS: The present study is a cross-sectional study of the analytical type with pregnant women paired by age and prepregnancy body mass index (BMI). Group 1 (G1) comprised 80 pregnant women without previous submission to RYGB and group 2 (G2) by 40 pregnant women who previously underwent this surgery. We used high-performance liquid chromatography with UV detector for quantification of retinol and β-carotene, and the functional evaluation of vitamin A deficiency (VAD) was performed through standardized interview validated for pregnant women. RESULTS: G1 mean age was 29.3 ± 5.3 and 30.8 ± 4.4 in G2. BMI mean prepregnancy found in G1 was 25.7 ± 3.2 and 26.8 ± 3.1 in G2, featuring overweight. Serum retinol and β-carotene means were significantly higher in G1 (1.8 ± 0.9; 87.4 ± 62.2) compared to G2 (0.99 ± 0.39; 22.7 ± 18.0), respectively (p < 0.001). Regarding the functional indicator for evaluation of VAD, approximately 75.0 % of pregnant women in G2 showed night blindness and 20.0 % in G1, and the percentage of pregnant women with this functional impairment was significantly higher in G2 compared to G1 with p < 0.001. CONCLUSION: Results show that pregnancy after RYGB can represent a high-risk situation for VAD. We recommend interdisciplinary monitoring added to the prenatal routine consultations and the conduction of studies addressed to the investigation of a safe and effective dose of oral supplementation of vitamin A to pregnant women undergoing RYGB.
Entities:
Keywords:
Bariatric surgery; Night blindness; Pregnancy; Roux-en-Y gastric bypass; Vitamin A
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