Sudhir Ken Mehta1. 1. Department of Pediatric Cardiology,Cleveland Clinic Lerner College of Medicine,Cleveland Clinic Children's,Cleveland,Ohio,United States of America.
Abstract
OBJECTIVES: Waist circumference to height ratio, a measure of central obesity, is a better predictor of cardiovascular risk than body mass index in the paediatric population. Increased left ventricular mass secondary to obesity and hypertension increases the risk for death and cardiovascular disease in adults. Similar data on left ventricular mass are lacking among young patients with central obesity, as defined by waist circumference/height. The present study evaluates left ventricular mass in young patients with central obesity as defined by waist circumference/height. METHODS: A total of 156 patients, 2- to 20-years old, without evidence of structural heart disease were studied. As the left ventricular mass is related to age and gender, 52 patients with central obesity - waist circumference/height ⩾0.55 - were randomly matched for age and gender with 52 patients at risk for central obesity - waist circumference/height ⩾0.5 to <0.55 - and 52 patients with no central obesity - waist circumference/height <0.5. The left ventricular mass parameters measured by echocardiography were compared across the three groups. RESULTS: Patients with central obesity had significantly (p<0.05) increased Z scores for left ventricular mass, left ventricular mass/height2.7, and left ventricular mass/height1.7 compared with patients at risk for central obesity and patients with no central obesity. Z scores for left ventricular mass were higher among patients at risk for central obesity compared with patients with no central obesity. CONCLUSIONS: Left ventricular mass data of the present study support maintaining an ideal waist circumference/height <0.5. Aggressive efforts to identify and manage patients with central obesity are warranted.
OBJECTIVES: Waist circumference to height ratio, a measure of central obesity, is a better predictor of cardiovascular risk than body mass index in the paediatric population. Increased left ventricular mass secondary to obesity and hypertension increases the risk for death and cardiovascular disease in adults. Similar data on left ventricular mass are lacking among young patients with central obesity, as defined by waist circumference/height. The present study evaluates left ventricular mass in young patients with central obesity as defined by waist circumference/height. METHODS: A total of 156 patients, 2- to 20-years old, without evidence of structural heart disease were studied. As the left ventricular mass is related to age and gender, 52 patients with central obesity - waist circumference/height ⩾0.55 - were randomly matched for age and gender with 52 patients at risk for central obesity - waist circumference/height ⩾0.5 to <0.55 - and 52 patients with no central obesity - waist circumference/height <0.5. The left ventricular mass parameters measured by echocardiography were compared across the three groups. RESULTS:Patients with central obesity had significantly (p<0.05) increased Z scores for left ventricular mass, left ventricular mass/height2.7, and left ventricular mass/height1.7 compared with patients at risk for central obesity and patients with no central obesity. Z scores for left ventricular mass were higher among patients at risk for central obesity compared with patients with no central obesity. CONCLUSIONS: Left ventricular mass data of the present study support maintaining an ideal waist circumference/height <0.5. Aggressive efforts to identify and manage patients with central obesity are warranted.
Entities:
Keywords:
Central obesity; Z score for left ventricular mass; left ventricular mass/Ht1.7; left ventricular mass/Ht2.7
Authors: Kristen Sgambat; Jennifer Roem; Mark Mitsnefes; Anthony A Portale; Susan Furth; Bradley Warady; Asha Moudgil Journal: Pediatr Nephrol Date: 2018-06-05 Impact factor: 3.714