Aminah Jatoi1, Hyman Muss2, Jake B Allred3, Harvey J Cohen4, Karla Ballman3, Judith O Hopkins5, Ajeet Gajra6, Jacqueline Lafky7, Antonio Wolff8, Lisa Kottschade1, Julie Gralow9, Arti Hurria10. 1. Department of Oncology, Mayo Clinic, Rochester, MN, USA. 2. University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA. 3. Alliance Statistics and Data Center, Mayo Clinic, Rochester, MN, USA. 4. Department of Medicine and Center for the Study of Aging and Human Development, Duke University, Durham, NC, USA. 5. Novant Health Oncology Specialists, Winston Salem, NC, USA. 6. Department of Medicine, State University of New York Upstate Medical University, Syracuse, NY, USA. 7. Cancer Center Clinical Research Offices, Mayo Clinic, Rochester, MN, USA. 8. Department of Oncology, Johns Hopkins University, Baltimore, MD, USA. 9. Division of Medical Oncology, University of Washington, Seattle, WA, USA. 10. City of Hope, Duarte, CA, USA.
Abstract
BACKGROUND: Studies point to a direct association between social support and better cancer outcomes. This study examined whether baseline social support is associated with better survival and fewer chemotherapy-related adverse events in older, early-stage breast cancer patients. METHODS: This study is a pre-planned secondary analysis of CALGB 49907/Alliance A171301, a randomized trial that compared standard adjuvant chemotherapy versus capecitabine in breast cancer patients 65 years of age or older. A subset reported on the extent of their social support with questionnaires that were completed 6 times over 2 years. RESULTS:The median age of this 331-patient cohort was 72 years (range: 65, 90); 179 (55%) were married, and 210 (65%) lived with someone. One hundred forty-five patients (46%) described a social network of 0-10 people; 110 (35%) of 11-25; and 58 (19%) of 26 or more. The Medical Outcomes Study (MOS) social support survey revealed that the median scores (range) for emotional/informational, tangible, positive social interaction, and affectionate social support were 94 (3, 100), 94 (0, 100), 96 (0, 100), and 100 (8, 100), respectively. Social support scores appeared stable over 2 years and higher (more support) than in other cancer settings. No statistically significant associations were observed between social support and survival and adverse events in multivariate analyses. However, married patients had smaller tumors, and those with arthritis reported less social support. CONCLUSION: Although social support did not predict survival and adverse events, the exploratory but plausible inverse associations with larger tumors and arthritis suggest that social support merits further study.
RCT Entities:
BACKGROUND: Studies point to a direct association between social support and better cancer outcomes. This study examined whether baseline social support is associated with better survival and fewer chemotherapy-related adverse events in older, early-stage breast cancerpatients. METHODS: This study is a pre-planned secondary analysis of CALGB 49907/Alliance A171301, a randomized trial that compared standard adjuvant chemotherapy versus capecitabine in breast cancerpatients 65 years of age or older. A subset reported on the extent of their social support with questionnaires that were completed 6 times over 2 years. RESULTS: The median age of this 331-patient cohort was 72 years (range: 65, 90); 179 (55%) were married, and 210 (65%) lived with someone. One hundred forty-five patients (46%) described a social network of 0-10 people; 110 (35%) of 11-25; and 58 (19%) of 26 or more. The Medical Outcomes Study (MOS) social support survey revealed that the median scores (range) for emotional/informational, tangible, positive social interaction, and affectionate social support were 94 (3, 100), 94 (0, 100), 96 (0, 100), and 100 (8, 100), respectively. Social support scores appeared stable over 2 years and higher (more support) than in other cancer settings. No statistically significant associations were observed between social support and survival and adverse events in multivariate analyses. However, married patients had smaller tumors, and those with arthritis reported less social support. CONCLUSION: Although social support did not predict survival and adverse events, the exploratory but plausible inverse associations with larger tumors and arthritis suggest that social support merits further study.
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Authors: Hyman B Muss; Donald A Berry; Constance T Cirrincione; Maria Theodoulou; Ann M Mauer; Alice B Kornblith; Ann H Partridge; Lynn G Dressler; Harvey J Cohen; Heather P Becker; Patricia A Kartcheske; Judith D Wheeler; Edith A Perez; Antonio C Wolff; Julie R Gralow; Harold J Burstein; Ahmad A Mahmood; Gustav Magrinat; Gutav Magrinat; Barbara A Parker; Ronald D Hart; Debjani Grenier; Larry Norton; Clifford A Hudis; Eric P Winer Journal: N Engl J Med Date: 2009-05-14 Impact factor: 91.245
Authors: N Cavalli-Björkman; C Qvortrup; S Sebjørnsen; P Pfeiffer; T Wentzel-Larsen; B Glimelius; H Sorbye Journal: Br J Cancer Date: 2012-05-10 Impact factor: 7.640
Authors: Araba Adjei; Jan C Buckner; Elizabeth Cathcart-Rake; Hongbin Chen; Harvey J Cohen; Dyda Dao; Jo-Ellen De Luca; Josephine Feliciano; Rachel A Freedman; Richard M Goldberg; Judith Hopkins; Joleen Hubbard; Aminah Jatoi; Meghan Karuturi; Margaret Kemeny; Gretchen G Kimmick; Heidi D Klepin; Jessica L Krok-Schoen; Jacqueline M Lafky; Jennifer G Le-Rademacher; Daneng Li; Stuart M Lichtman; Ronald Maggiore; Jeanne Mandelblatt; Vicki A Morrison; Hyman B Muss; Michael O Ojelabi; Mina S Sedrak; Niveditha Subbiah; Virginia Sun; Susan Tuttle; Noam VanderWalde; Tanya Wildes; Melisa L Wong; Jennifer Woyach Journal: J Geriatr Oncol Date: 2019-06-11 Impact factor: 3.599
Authors: Hyman B Muss; Mei-Yin C Polley; Donald A Berry; Heshan Liu; Constance T Cirrincione; Maria Theodoulou; Ann M Mauer; Alice B Kornblith; Ann H Partridge; Lynn G Dressler; Harvey J Cohen; Patricia A Kartcheske; Edith A Perez; Antonio C Wolff; Julie R Gralow; Harold J Burstein; Ahmad A Mahmood; Linda M Sutton; Gustav Magrinat; Barbara A Parker; Ronald D Hart; Debjani Grenier; Arti Hurria; Aminah Jatoi; Larry Norton; Clifford A Hudis; Eric P Winer; Lisa Carey Journal: J Clin Oncol Date: 2019-07-24 Impact factor: 44.544
Authors: Siao-Nge Hoon; Peter Kh Lau; Alison M White; Max K Bulsara; Patricia D Banks; Andrew D Redfern Journal: Cochrane Database Syst Rev Date: 2021-05-26