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Literature DB >> 25994065

Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research.

Don Daniel Nwibo¹, Hiroshi Hamamoto, Yasuhiko Matsumoto, Chikara Kaito, Kazuhisa Sekimizu.

Abstract

We advocate the use of silkworm larvae, Bombyx mori, as an animal model for discovery of drug candidates. We have established several disease models using silkworms, which offer technical advantages in drug development and the study of host-pathogen interaction. This mini review briefly describes recent trends in the use of silkworm larvae as a non-mammalian model for drug discovery and it offers suggestions regarding the potential for silkworm use in pharmaceutical-biomedical research.

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Year: 2015 PMID： 25994065 DOI： 10.5582/ddt.2015.01026

Source DB: PubMed Journal: Drug Discov Ther ISSN： 1881-7831

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Cited

11 in total

1. Silkworm, Bombyx mori, as an alternative model organism in toxicological research.

Authors: Nouara Abdelli; Lü Peng; Chen Keping
Journal: Environ Sci Pollut Res Int Date: 2018-10-29 Impact factor: 4.223

2. Estrogen-Related Receptor Influences the Hemolymph Glucose Content by Regulating Midgut Trehalase Gene Expression in the Last Instar Larvae of Bombyx mori.

Authors: Guanwang Shen; Jinxin Wu; Ying Lin; Xiaoting Hua; Qingyou Xia; Ping Zhao
Journal: Int J Mol Sci Date: 2021-04-21 Impact factor: 5.923

Review 3. An Update on Candida tropicalis Based on Basic and Clinical Approaches.

Authors: Diana L Zuza-Alves; Walicyranison P Silva-Rocha; Guilherme M Chaves
Journal: Front Microbiol Date: 2017-10-13 Impact factor: 5.640

4. Serine protease Bm-SP142 was differentially expressed in resistant and susceptible Bombyx mori strains, involving in the defence response to viral infection.

Authors: Guohui Li; Qian Zhou; Lipeng Qiu; Qin Yao; Keping Chen; Qi Tang; Zhaoyang Hu
Journal: PLoS One Date: 2017-04-17 Impact factor: 3.240

10. Products of Sericulture and Their Hypoglycemic Action Evaluated by Using the Silkworm, Bombyx mori (Lepidoptera: Bombycidae), as a Model.

Authors: Salvador D Aznar-Cervantes; Beatriz Monteagudo Santesteban; José L Cenis
Journal: Insects Date: 2021-11-25 Impact factor: 2.769

Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research.

1. Silkworm, Bombyx mori, as an alternative model organism in toxicological research.

2. Estrogen-Related Receptor Influences the Hemolymph Glucose Content by Regulating Midgut Trehalase Gene Expression in the Last Instar Larvae of Bombyx mori.

Review 3. An Update on Candida tropicalis Based on Basic and Clinical Approaches.

4. Serine protease Bm-SP142 was differentially expressed in resistant and susceptible Bombyx mori strains, involving in the defence response to viral infection.

5. Influence of hyperproteinemia on reproductive development in an invertebrate model.

6. Virulence of Clinical Candida Isolates.

Review 7. Zebrafish: An Attractive Model to Study Staphylococcus aureus Infection and Its Use as a Drug Discovery Tool.

Review 8. Silkworm: A Promising Model Organism in Life Science.

9. Proteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line.

10. Products of Sericulture and Their Hypoglycemic Action Evaluated by Using the Silkworm, Bombyx mori (Lepidoptera: Bombycidae), as a Model.