[Regional peculiarities of the distribution of innate and adaptive immune cells in different segments of the intestine as factor determining the localization of the pathological process].

The intestine represents the largest compartment of the immune system. Gut-associated lymphoid tissue (GALT) is a sensor region for luminal content and plays an important role in lymphoid maturation, activation and differentiation. We studied the regional peculiarities of the distribution of T-bet+ (Thl), GATA-3+ (Th2), RORγt+ (Th17), Foxp3+ (Treg) immunopositive lymphocytes and TLR2-, TLR4-, NOD- and RIG-like expression levels by lymphocytes of the gut-associated lymphoid tissue in the intestine of Wistar rats. The immunopositive lymphocytes were determined using an indirect immunofluorescence technique with using a monoclonal rat antibody. We have found regional differences distribution of immune cell populations along the length of the intestine.