Evaluation of quality of life pre- and post-vestibular rehabilitation in patients with benign paroxysmal positional vertigo associated with Meniere's disease.

INTRODUCTION: Vertigo is a symptom that impacts the patients' quality of life and may force them to cease performing activities of daily living. Here, we discuss benign paroxysmal positional vertigo (BPPV) and Meniere's disease (MD), which show exacerbated symptoms when they appear in association. Vestibular rehabilitation (VR) is an effective treatment in reducing vertigo, especially in conjunction with other therapies. AIM: To evaluate the quality of life of patients with BPPV and MD before and after VR.
METHOD: We conducted a descriptive observational qualitative and quantitative case study with 12 patients aged 35 to 86 years. All patients diagnosed with BPPV and MD received treatment in the ENT clinic. The Brazilian DHI questionnaire, which assesses the quality of life with a focus on physical, emotional, and functional aspects, was used for data collection, and was completed by patients before the first session and after the fifth session of VR. Data were tested using the Shapiro-Wilk normality test, followed by Wilcoxon, Friedman, and Spearman correlation tests (p < 0.05).
RESULTS: There were significant improvements in scores for all aspects, with median changes ranging from 12 to 0 in the physical, 6 to 1 in the emotional, and 11 to 1 in the functional aspect. There were no correlations between the scores and sample characteristics.
CONCLUSION: VR was an effective method for the treatment of patients with BPPV and MD; it improves quality of life and shows the maximal influence on physical aspect scores, regardless of age or gender.

Introduction

Dizziness has a high incidence worldwide, and the impact of vestibular disease on quality of life has been increasingly investigated. Many patients with dizziness restrict their daily activities and leisure in order to reduce the risk of onset of unpleasant and frightening symptoms, as well as to avoid the social embarrassment and stigma that these symptoms may cause1.

Benign paroxysmal positional vertigo (BPPV) is a disease with a high incidence worldwide, and can be regarded as the most frequent vestibular disease2. There are few studies correlating BPPV and Meniere's disease (MD) and their combined influence on the quality of life of patients3 4. Simultaneous diagnosis of BPPV and MD may worsen symptoms of dizziness and thus worsen the quality of life, because the discomfort caused by these symptoms can significantly change the ability of patients to perform their usual tasks4.

Among existing evaluation instruments, the Dizziness Handicap Inventory (DHI) is an internationally validated instrument. This questionnaire assesses patients' perception of the effects of the disabling vertigo on their quality of life, including the physical, emotional, and functional aspects. It is important to assess the individual's condition at the beginning of treatment and to monitor the evolution of the disease course1 (Chart 1).

Chart 1.

Dizziness Handicap Inventory (DHI) - Brazilian version.

Questions		Yes	No	Sometimes
1.	Does looking up increase your problem?	( )	( )	( )
2.	Because of your problem, do you feel frustrated?	( )	( )	( )
3.	Because your problem, do you restrict your travel for business or recreation?	( )	( )	( )
4.	Does walking down the aisle of a supermarket increase your problem?	( )	( )	( )
5.	Because your problem, do you have difficulty getting into or out of bed?	( )	( )	( )
6.	Does your problem significantly restrict your participation in social activities such as going out to dinner, going to movies, dancing, or to parties?	( )	( )	( )
7.	Because your problem, do you have difficulty reading?	( )	( )	( )
8.	Does performing more vigorous activities such as sports, dancing, or household chores such as sweeping or putting dishes away increase your problem?	( )	( )	( )
9.	Because your problem, are you afraid to leave home without having someone with you?	( )	( )	( )
10.	Because your problem, have you been embarrassed in front of others?	( )	( )	( )
11.	Do quick movements of your head increase your problem?	( )	( )	( )
12.	Because your problem, do you avoid heights?	( )	( )	( )
13.	Does turning over in bed increase your problem?	( )	( )	( )
14.	Because your problem, is it difficult for you to do strenuous housework or yard work?	( )	( )	( )
15.	Because your problem, are you afraid people may think you are intoxicated or drunk?	( )	( )	( )
16.	Because your problem, is it difficult for you to go for a walk by yourself?	( )	( )	( )
17.	Does walking down a sidewalk increase your problem?	( )	( )	( )
18.	Because your problem, is it difficult for you to concentrate?	( )	( )	( )
19.	Because your problem, is it difficult for you walk around your house in the dark?	( )	( )	( )
20.	Because your problem, are you afraid to stay home alone?	( )	( )	( )
21.	Because your problem, do you feel handicapped?	( )	( )	( )
22.	Has your problem placed stress on your relationship with members of your family or your friends?	( )	( )	( )
23.	Because your problem, are you depressed?	( )	( )	( )
24.	Does your problem interfere with your job or household responsibilities?	( )	( )	( )
25.	Does bending over increase your problem?	( )	( )	( )

Legend: Physical aspects - Questions 1, 4, 8, 11, 13, 17 and 25; Functional aspects - Questions 3, 5, 6, 7, 12, 14, 16, 19 and 24, Emotional aspects - Questions 2, 9, 10, 15, 18, 20, 21, 22 and 23. Each YES answer = 4 points; SOMETIMES = 2 points; NO = 0 points. The final score is the sum of points obtained in all aspects.

Treatment options for vertigo patients include medications, vestibular rehabilitation (VR) and, more rarely, surgical procedures5. VR has been used as a strategy for the treatment of vestibular disorders because its goals are to provide security to the patient and integrate them into their social environment. VR aims to promote visual stabilization, improve static and dynamic balance, decrease sensitivity during head movement, and improve the overall function of the patient via proprioceptive and vestibular visual stimulation maneuvers6.

The objective of this study was to evaluate the pre- and post-VR quality of life of patients with MD-associated BPPV by using the Brazilian version of the DHI as an evaluation tool.

Method

The study was approved by the Ethics in Research on Humans Foundation Regional University of Blumenau (FURB), under protocol 180/09. The sample consisted of 12 patients of both genders with a diagnosis of Meniere's disease associated with benign paroxysmal positional vertigo (BPPV) of the posterior canal, who were seen at the ENT clinic during the period from October to December 2009. Inclusion criteria were as follows: clinical diagnosis of Meniere's disease with complementary electrocochleographic findings, presence of nystagmus triggered by Dix Hill Pike maneuvers and lateral placement test identified under the guidance of videonystagmography, no treatment initiation or maintenance during the period between surveys, agreement to undergo surgery to the ear, and agreement to signing a consent form. We excluded patients with signs and symptoms of vestibular central origin, those with musculoskeletal abnormalities that impair the performance of the maneuvers (diagnostic and therapeutic), individuals who began vestibular rehabilitation before completing the questionnaire, and patients undergoing vestibular rehabilitation lasting less than 5 sessions, considering the research period.

The sessions were held once a week individually, with each session lasting 1 hour. VR started with the canalith repositioning maneuver of Epley, where the individual sitting on the table adopts a supine position and the therapist rotates the head to the side of the affected labyrinth. After a minute, the head is rotated to the opposite side and the patient is instructed to stay in the same position for another minute, returning to a seated position at the end. This was followed by the Brandt and Daroff habituation exercises. From the seated position on the table, the patient adopts a lateral recumbent position (first on the side that causes the dizziness), maintains the position for 30 seconds or until the dizziness passes, changes to a lateral seated position, waits for the same time period, and then lies on the opposite side and waits for 30 seconds. Each patient was taught the exercises and instructed to repeat them at home 10–20 times a day. In addition, we performed the Cawthorne-Cooksey visual exercises consisting of up and down and side-to-side eye movements as well as extension of an arm and focusing on the finger as it approaches and moves away from the face. All movements were repeated 20 times, starting slowly and becoming progressively faster, with the patient sitting or lying down. In another exercise, with the individual sitting or standing, only the head moved forward and back, after a back and forth motion; these motions were first performed slowly and then rapidly, with eyes open and progressing to accomplishment of each movement and with eyes closed for 1 minute. The Brazilian version of the DHI was completed by participants before undergoing the first session of VR and after the last treatment session. Subjects were instructed to mark the item that best demonstrated their perception of the influence of vertigo on their quality of life at the time, with doubts addressed by the researchers present during the survey. The absence of symptoms/problems was marked “no,” corresponding to 0 (zero), occasional presence of symptoms/problems was reported as “sometimes,” and was scored as 2 points, and the presence of severe symptoms/problems was marked “yes,” and amounted to 4 points. The minimum score of the questionnaire was 0 (zero) and the maximum was 100 points, with 7 items referring to physical aspects, 9 to functional aspects, and 9 to emotional aspects7.

For data analysis, we first used the Shapiro-Wilk test of normality, proceeding with the Wilcoxon test for comparisons between samples before and after vestibular rehabilitation, and the Friedman test to compare the impact of physical, emotional, and functional scores after standardizing the values by calculating the percentage according to the maximum possible score to be obtained on each item. Spearman correlation was used to evaluate the relationship between aspects, the total score, and the characteristics of the sample test. All analyses were processed in 4.0 BioEstat considering significance at p < 0.05.

Results

In the stipulated period for data collection, 12 individuals fulfilled the criteria for inclusion and exclusion. There were 4 (33.33%) men and 8 (66.66%) women, all Caucasian, aged between 35 and 86 years (mean, 53.17 ± 15.75 years). Three (25%) were less than 40 years old, 6 (50%) were aged between 40 and 59 years, and 3 (25%) were aged 60 years or more (Table 1).

Table 1.

Characterization of the sample. DHI (Brazilian version) pre- and post-vestibular rehabilitation (n = 12).

Patient	Age	Gender	DHI-pre	DHI-post	Difference between DHI pre and post
01	36	Male	60	12	48
02	86	Male	32	08	24
03	64	Male	12	0	12
04	35	Female	62	06	56
05	38	Female	44	22	22
06	50	Female	18	04	14
07	41	Female	14	0	14
08	57	Female	58	14	44
09	74	Female	60	04	56
10	48	Female	24	0	24
11	59	Male	14	0	14
12	50	Female	22	06	16

There was a significant reduction in all DHI values after VR, independent of the aspect. The median final values were 0 (zero) for the physical aspect, 1 for the emotional aspect, and 1 for the functional aspect, demonstrating the favorable impact of VR on the quality of life of our patients (Table 2). Generally, the score must be reduced by at least 18 after treatment to be indicative of benefit1. In our series, 7 (58.33%) patients showed a reduction greater than 18 points, 5 (41.67%) did not show a reduction greater than 18 points, and 3 (25%) did not achieve a pre-VR score large enough to show such a reduction. In the evaluation of post-VR scores, 2 (16.6%) patients who had scores less than 18 pre-VR, despite showing an improvement in the aspects evaluated, did not show score reductions of the specified magnitude.

Table 2.

Median score obtained by completing the DHI questionnaire (Brazilian version) pre- and post-vestibular rehabilitation. MD = median, AIQ = interquartile range (n = 12).

Variables	Pre	Post
Physical Aspect	MD	12	0*
	AIQ	09	04
	Mínimum - Maximum	0–24	0–10
Emotional Aspect	MD	06	01*
	AIQ	10	02
	Mínimum - Maximum	0–22	0–06
Functional Aspect	MD	11	01*
	AIQ	15.5	4.5
	Mínimum - Maximum	04–30	0–10
DHI total	MD	28	058*
	AIQ	41,5	09
	Mínimum - Maximum	12–62	0–22

p < 0.01 when compared to before.

To compare the effects on the different aspects, the raw score values were normalized as percentage values, with 100% indicating the maximum score in every aspect. Next, we compared the pre- and post-VR scores. In the preoperative evaluation, we noted that the diseases had a greater impact on physical and functional aspects than on the emotional aspect. Although none of the aspects showed a predominant effect of VR, the differences in the pre- and post-VR values showed that VR had the greatest influence on the physical aspect (Table 3).

Table 3.

Comparison between the influence of each aspect in the total score of DHI (Brazilian version) by means of percentage values obtained after normalization of the actual values for the maximum possible score to be obtained in every aspect pre- and post-vestibular rehabilitation. Where MD = median, AIQ = interquartile range (n = 12).

Variables		Pre (%)	Post (%)	Diference (%)
Physical Aspect	MD	42.85*	0	39.28*
	AIQ	32.14	14.28	17.86
	Mínimum - Maximum	0–85.71	0–35.71	0–64. 29
Emotional Aspect	MD	16.66	2.78	13.89
	AIQ	27.77	5.56	23.60
	Minimum Maximum	0–61.11	0–16.67	0–44.44
Functional Aspect	MD	30.55*	2.77	22.22
	AIQ	43.05	12.50	34.72
	Minimum Maximum	11.11–83.33	0–27.77	0–72.22

p < 0.05 when compared to emotional aspect

In the first evaluation (pre-VR), the correlation between the physical and functional aspects was moderately positive, and that between the emotional and functional aspects was strongly positive, indicating the interrelationship of these factors on quality of life of the volunteers, i.e., the functional aspect influences and is influenced by physical and emotional aspects. Post-RV, these correlations were not observed. However, analysis of the difference (pre - post) showed a weak positive correlation between the emotional and functional aspects (Table 4).

Table 4.

Correlation between the physical, emotional and functional aspects assessed in the DHI (Brazilian version) pre- and post-vestibular rehabilitation, as well as the difference between these steps. Where FIS = physical aspect, EM = emotional aspect, FUN = functional aspect, R = Spearman correlation coefficient (n = 12).

	Pre				Post				Diference
	EM		FUN		EM		FUN		EM		FUN
	(R)	(p)	(R)	(p)	(R)	(p)	(R)	(p)	(R)	(p)	(R)	(p)
FIS	0.47	0.12	0.60	0.04*	0.46	0.13	0.57	0.06	0.55	0.06	0.47	0.12
EM			0.87	0.002*			0.34	0.27			0.71	0.01*

where p < 0.05

In the pre- and post-VR analyses, there was a lack of correlation between age and gender with the DHI scores, indicating that the results of the VR were not affected by these characteristics (Table 5).

Table 5.

Correlation between the score of DHI (Brazilian version) and the variables age and gender in pre- and post vestibular rehabilitation. Where R = Spearman correlation coefficient (n = 12).

Variable	Dizziness Handicap Inventory (DHI)–Brazilian version
	Pre		Post
	R	p	R	P
Age	0,147	0,647	-0,213	0,506
Gender	-0,308	0,329	-0,157	0,626

It should be noted that the sample size did not allow generalization of the results; however, considering the results, the importance of VR is evident. In another study with 15 subjects who were diagnosed as having BPPV associated with Ménière's disease, the physical aspect was the most affected4, but there are few studies analyzing both conditions together and using VR for the treatment of this combination.

Discussion

Regarding gender, there was a predominance of women (75%) in the sample, which agrees with previous studies that found a prevalence of dizziness and BPPV in 61.3% to 62.5% of female patients8 9 10. Some authors suggest that the variations in natural hormones in women could be related to this increased incidence, but did not elucidate this theory11. As for Meniere's disease (MD) alone, there are reports of an equal distribution between genders12. The most prevalent age group in this study also coincides with the findings obtained by other authors, who indicated that 48% to 60% of subjects were between 41 and 60 years of age4 7.

All individuals in the sample were diagnosed with MD and associated BPPV. Other studies have also reported the coexistence of these 2 diseases, with patients initially presenting symptoms of MD followed by symptoms of BPPV13 14. One hypothesis for this relationship between the 2 diseases is the possible release of otoconia by damage to the utricle by endolymphatic hydrops and hypertension3.

The DHI-Brazilian version was used to assess the impact of VR on the quality of life of patients and, based on the significant score decrease in most patients, it is argued that VR is favorable for these patients. The dizziness and other symptoms that often accompany vestibular disorders may manifest during social, familial, and professional activities, thus causing physical, financial, and psychological distress to the patients15 16 17 and necessitating interventions to eliminate or minimize these symptoms. Individuals end up restricting their head movements and activities to prevent vertigo, thereby imposing physical constraints that lead to functional loss and consequent emotional turmoil, which explains the damage caused by these disorders.

We found that pre-VR, the greatest impact was noted on the physical and functional aspects while after VR, the greatest influence was noted on the physical aspect, despite the reduction of the values in the functional and emotional aspects as well. It was noted that after the improvement in physical symptoms, individuals were able to resume their routine activities that were previously restricted due to dizziness or fear of symptoms, and this improvement consequently improved functional and emotional aspects, which are dependent on the physical aspects. This result contrasts the results of a previous study18, where a sample of 6 patients, aged 43–70 years, with complaints of dizziness and tinnitus showed no significant improvement in the functional and emotional aspects and no improvement in the physical aspect after VR.

It should be noted that apart from vertigo, some individuals had age-related comorbidities (such as osteoarthritis and osteoporosis), which by itself has limited some of the emotional issues such as fear of high places and fear of being alone at home or going out unaccompanied. Therefore, it is likely that the answers to these questions were influenced by comorbidities, so it is not possible to separate them from the symptom of vertigo/dizziness. This situation indicates that the analysis of the emotional aspect should be undertaken with care, because if the individual is unable to perform some physical activity for problems not related to dizziness, even after the improvement of vertigo, he/she will be unable to do the same.

The correlation between the physical and functional aspects and between emotional and functional aspects in pre-VR assessments demonstrates the interrelationship of these factors with the quality of life of individuals, i.e., the functional aspect influences and is influenced by the physical and emotional aspects. However, this effect appears to be greater when the symptoms are exacerbated by vertigo, since after VR, no such correlation was observed. The relationship between the functional and physical aspects is also highlighted in other studies, where the similar scores for these aspects were explained by the fact that in BPPV, onset of symptoms is closely related to certain positions or head movements, the relevant questions for which are contained in both aspects of IHL-Brazilian version19 20.

Similarly, studies involving individuals with MD associated with higher scores on the physical and functional aspects to the chronic nature of the disease with clinical manifestations floating, recurrent and lasting, that can compromise not only physical, but also the functionality of these patients4 21. In another study with 6 patients aged 43–70 years, the analysis of the DHI questionnaire after VR showed that patients experienced an improvement in functional and emotional aspects, although the difference was not significant18. Furthermore, the relationship of the functional to the emotional aspects can be understood by the rationale that when there is improved functionality, the individual returns to his/her daily habits, accomplishing all movements restricted before the onset of vertigo. Thus, the individual becomes more confident with regard to leaving the house without company and can simply raise the head or turn over in bed without being afraid of triggering symptoms.

The results of VR were not affected by age and/or gender, similar to previous studies that indicate no relationship between improvement in patients with vertigo and after VR with these variables20 22. In this context, the geriatric population responds to treatment as well as a younger population, but most of the elderly patients require a greater number of treatment sessions to achieve the same result as the young23. Moreover, other studies describe that age is not necessarily associated with loss of independence in activities of daily living, and therefore, it is not possible to relate the age-diminished ability with greater independence or improvement in vertigo after vestibular alteration24. On the other hand, dizziness has a more detrimental effect on quality of life of elderly than in younger adults, according to studies with these populations25 26 27 28. Regarding gender, some authors report that the variable is not related to any advantage or disadvantage in relation to response to treatment7, a fact verified by the results presented here. As individuals in the sample were out of the crisis period during the questionnaire analysis and underwent VR, the results discussed are restricted to perception of symptoms by individuals on a daily basis, whereas in vertigo, the symptoms are exacerbated.

Finally, we would like to point out the importance of multidisciplinary medical and physiotherapy in the diagnosis and treatment to achieve greater security and adherence to this treatment modality.

Conclusions

The results obtained through the DHI Brazilian version show that the quality of life of patients with BPPV associated with MD improved after 5 sessions of VR in all aspects analyzed. We noticed that the diseases had a greater impact on the physical and functional aspects of quality of life before VR, with the highest rate of improvement noted in the perception of physical appearance after the therapy. Age and gender did not affect the response to treatment. Although the sample consisted of a small number of patients, the results obtained with VR were surprising and further studies need to be developed, especially involving the 2 pathologies. Moreover, the VR was well accepted by volunteers who showed increased enthusiasm and confidence with the evolution of treatment and reduction of symptoms.