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Literature DB >> 2599112

Phospholipase D activation by the mitogens platelet-derived growth factor and 12-O-tetradecanoylphorbol 13-acetate in NIH-3T3 cells.

Abstract

The effect of mitogens on phospholipase D activity was investigated in NIH-3T3 fibroblasts by measuring the accumulation of phosphatidylpropanol, produced by phospholipase D phosphatidyl transferase activity when 1-propanol acts as the phosphatidyl group acceptor. Platelet-derived growth factor (PDGF) and 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated phosphatidylpropanol production by the cells. The dose-response relationships for activation of phospholipase D and stimulation of thymidine incorporation by PDGF and TPA were comparable. The possibility that activation of phospholipase D is utilized by mitogens as a trans-membrane pathway for signalling cell growth is discussed.

Entities: Chemical

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Year: 1989 PMID： 2599112 DOI： 10.1016/0014-5793(89)81495-4

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

16 in total

1. Platelet-derived growth factor activates phospholipase D and chemotactic responses in vascular smooth muscle cells.

Authors: C J Welsh; K Schmeichel; K McBride
Journal: In Vitro Cell Dev Biol Date: 1991-05

2. Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown.

Authors: T Fu; Y Okano; Y Nozawa
Journal: Biochem J Date: 1992-04-15 Impact factor: 3.857

3. Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells.

Authors: B Geny; S Cockcroft
Journal: Biochem J Date: 1992-06-01 Impact factor: 3.857

4. Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.

Authors: L del Peso; L Lucas; P Esteve; J C Lacal
Journal: Biochem J Date: 1997-03-01 Impact factor: 3.857

5. Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function.

Authors: S A Metz; M Dunlop
Journal: Biochem J Date: 1990-09-01 Impact factor: 3.857

10. Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.

Authors: J K Pai; J A Pachter; I B Weinstein; W R Bishop
Journal: Proc Natl Acad Sci U S A Date: 1991-01-15 Impact factor: 11.205

Phospholipase D activation by the mitogens platelet-derived growth factor and 12-O-tetradecanoylphorbol 13-acetate in NIH-3T3 cells.

1. Platelet-derived growth factor activates phospholipase D and chemotactic responses in vascular smooth muscle cells.

2. Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown.

3. Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells.

4. Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.

5. Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function.

Review 6. Sphingolipid metabolites: members of a new class of lipid second messengers.

7. NC-mediated nucleolar localization of retroviral gag proteins.

8. Activation and solubilization by Triton X-100 of membrane-bound phospholipase D of rat brain.

9. Transmodulation between phospholipase D and c-Src enhances cell proliferation.

10. Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.