Apoorva Saboo1, Ayeshmanthe Rathnayake1, Venkat N Vangaveti1, Usman H Malabu2. 1. Translational Research in Endocrinology and Diabetes [TREAD], College of Medicine and Dentistry, James Cook University, The Townsville Hospital, 100 Angus Smith Drive, Douglas 4814, QLD, Australia. 2. Translational Research in Endocrinology and Diabetes [TREAD], College of Medicine and Dentistry, James Cook University, The Townsville Hospital, 100 Angus Smith Drive, Douglas 4814, QLD, Australia. Electronic address: usman.malabu@jcu.edu.au.
Abstract
OBJECTIVE: Dipeptidyl peptidase-4 (DPP-4) inhibitors have a well-known effect on glycaemic control in patients with diabetes but little is known on their wound healing role in this group of population. This paper reviews the effects of DPP-4 inhibitors on wound healing of diabetic foot ulcers. METHODS: Published data on effects and mechanism of DDP-4 inhibitors on wound healing were derived from Medline, PubMed and Google Scholar search of English language literature from 1994 to 2014 using the key words such as "DPP-4 inhibitors", "endothelial healing" "diabetes" and "chronic ulcers". RESULTS: DPP-4 inhibitors show a potential benefit in processes of wound healing in diabetic chronic foot ulcers. The enzyme inhibitors promote recruitment of endothelial progenitor cells and allow the final scaffolding of wounds. Furthermore DPP-4 inhibitors augment angiogenesis and have widespread effects on optimising the immune response to persistent hypoxia in chronic diabetes wounds. CONCLUSION: DPP-4 inhibitors show promise in the local wound healing of diabetic foot ulcers in addition to its already established glycaemic control. In the light of high rate of amputations due to non-healing ulcers with profound psychological and economical liability, more investigations on the usefulness of DPP-4 inhibitors in the high risk diabetes population are needed.
OBJECTIVE:Dipeptidyl peptidase-4 (DPP-4) inhibitors have a well-known effect on glycaemic control in patients with diabetes but little is known on their wound healing role in this group of population. This paper reviews the effects of DPP-4 inhibitors on wound healing of diabetic foot ulcers. METHODS: Published data on effects and mechanism of DDP-4 inhibitors on wound healing were derived from Medline, PubMed and Google Scholar search of English language literature from 1994 to 2014 using the key words such as "DPP-4 inhibitors", "endothelial healing" "diabetes" and "chronic ulcers". RESULTS:DPP-4 inhibitors show a potential benefit in processes of wound healing in diabetic chronic foot ulcers. The enzyme inhibitors promote recruitment of endothelial progenitor cells and allow the final scaffolding of wounds. Furthermore DPP-4 inhibitors augment angiogenesis and have widespread effects on optimising the immune response to persistent hypoxia in chronic diabetes wounds. CONCLUSION:DPP-4 inhibitors show promise in the local wound healing of diabetic foot ulcers in addition to its already established glycaemic control. In the light of high rate of amputations due to non-healing ulcers with profound psychological and economical liability, more investigations on the usefulness of DPP-4 inhibitors in the high risk diabetes population are needed.
Authors: Ewa Klara Stuermer; M Besser; N Terberger; V Koester; H S Bachmann; A L Severing Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2018-12-07 Impact factor: 3.000
Authors: Evelina Vågesjö; Emelie Öhnstedt; Anneleen Mortier; Hava Lofton; Fredrik Huss; Paul Proost; Stefan Roos; Mia Phillipson Journal: Proc Natl Acad Sci U S A Date: 2018-02-05 Impact factor: 11.205