Literature DB >> 2598977

Bioavailability of suckable tablets of oral N-acetylcysteine in man.

M De Bernardi di Valserra1, G Mautone, E Barindelli, P Lualdi, F Feletti, M R Galmozzi.   

Abstract

The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.

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Year:  1989        PMID: 2598977     DOI: 10.1007/bf00558514

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN: 0031-6970            Impact factor:   2.953


  9 in total

1.  THE IN VITRO REDUCTION IN VISCOSITY OF HUMAN TRACHEOBRONCHIAL SECRETIONS BY ACETYLCYSTEINE.

Authors:  A L SHEFFNER; E M MEDLER; L W JACOBS; H P SARETT
Journal:  Am Rev Respir Dis       Date:  1964-11

2.  The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteine.

Authors:  A L SHEFFNER
Journal:  Ann N Y Acad Sci       Date:  1963-03-30       Impact factor: 5.691

3.  PKCALC: a BASIC interactive computer program for statistical and pharmacokinetic analysis of data.

Authors:  R C Shumaker
Journal:  Drug Metab Rev       Date:  1986       Impact factor: 4.518

4.  [Multicenter, double-blind study of oral acetylcysteine vs. placebo].

Authors:  H Brocard; J Charpin; J Germouty
Journal:  Eur J Respir Dis Suppl       Date:  1980

5.  Toxicological, pharmacokinetic and metabolic studies on acetylcysteine.

Authors:  L Bonanomi; A Gazzaniga
Journal:  Eur J Respir Dis Suppl       Date:  1980

6.  Biological properties of acetylcysteine: assay development and pharmacokinetic studies.

Authors:  J Maddock
Journal:  Eur J Respir Dis Suppl       Date:  1980

7.  High-performance liquid chromatographic determination of N-acetylcysteine in human serum following acetaminophen overdosage.

Authors:  M R Holdiness; L R Morgan; L E Gillen; E F Harrison
Journal:  J Chromatogr       Date:  1986-10-31

8.  Pharmacokinetics of oral acetylcysteine: absorption, binding and metabolism in patients with respiratory disorders.

Authors:  D Rodenstein; A DeCoster; A Gazzaniga
Journal:  Clin Pharmacokinet       Date:  1978 May-Jun       Impact factor: 6.447

9.  Lung protection by a thiol-containing antioxidant: N-acetylcysteine.

Authors:  P Moldéus; I A Cotgreave; M Berggren
Journal:  Respiration       Date:  1986       Impact factor: 3.580

  9 in total

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