Literature DB >> 25989727

Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application.

Ryan E Mewis1, Marianna Fekete, Gary G R Green, Adrian C Whitwood, Simon B Duckett.   

Abstract

The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.

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Year:  2015        PMID： 25989727     DOI： 10.1039/c5cc01896j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Toward Cleavable Metabolic/pH Sensing "Double Agents" Hyperpolarized by NMR Signal Amplification by Reversible Exchange.

Authors:  Bryce E Kidd; Jamil A Mashni; Miranda N Limbach; Fan Shi; Eduard Y Chekmenev; Yuqing Hou; Boyd M Goodson
Journal:  Chemistry       Date:  2018-06-29       Impact factor: 5.236

2.  Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange.

Authors:  Peter J Rayner; Michael J Burns; Alexandra M Olaru; Philip Norcott; Marianna Fekete; Gary G R Green; Louise A R Highton; Ryan E Mewis; Simon B Duckett
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-04       Impact factor: 11.205

3.  Order-Unity 13 C Nuclear Polarization of [1-13 C]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement.

Authors:  Isaiah Adelabu; Patrick TomHon; Mohammad S H Kabir; Shiraz Nantogma; Mustapha Abdulmojeed; Iuliia Mandzhieva; Jessica Ettedgui; Rolf E Swenson; Murali C Krishna; Thomas Theis; Boyd M Goodson; Eduard Y Chekmenev
Journal:  Chemphyschem       Date:  2021-12-09       Impact factor: 3.102

4.  Parahydrogen Hyperpolarization Allows Direct NMR Detection of α-Amino Acids in Complex (Bio)mixtures.

Authors:  Lisanne Sellies; Ruud L E G Aspers; Martin C Feiters; Floris P J T Rutjes; Marco Tessari
Journal:  Angew Chem Int Ed Engl       Date:  2021-11-18       Impact factor: 16.823

Review 5.  Parahydrogen-Based Hyperpolarization for Biomedicine.

Authors:  Jan-Bernd Hövener; Andrey N Pravdivtsev; Bryce Kidd; C Russell Bowers; Stefan Glöggler; Kirill V Kovtunov; Markus Plaumann; Rachel Katz-Brull; Kai Buckenmaier; Alexej Jerschow; Francesca Reineri; Thomas Theis; Roman V Shchepin; Shawn Wagner; Pratip Bhattacharya; Niki M Zacharias; Eduard Y Chekmenev
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-01       Impact factor: 15.336

6.  Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability.

Authors:  Marianna Fekete; Peter J Rayner; Gary G R Green; Simon B Duckett
Journal:  Magn Reson Chem       Date:  2017-06-20       Impact factor: 2.447

7.  Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study.

Authors:  Anand Manoharan; Peter J Rayner; Wissam Iali; Michael J Burns; V Hugh Perry; Simon B Duckett
Journal:  ChemMedChem       Date:  2018-01-18       Impact factor: 3.466

8.  Efficient Synthesis of Nicotinamide-1-¹⁵N for Ultrafast NMR Hyperpolarization Using Parahydrogen.

Authors:  Roman V Shchepin; Danila A Barskiy; Dmitry M Mikhaylov; Eduard Y Chekmenev
Journal:  Bioconjug Chem       Date:  2016-03-24       Impact factor: 4.774

9.  A New Ir-NHC Catalyst for Signal Amplification by Reversible Exchange in D2 O.

Authors:  Peter Spannring; Indrek Reile; Meike Emondts; Philipp P M Schleker; Niels K J Hermkens; Nick G J van der Zwaluw; Bram J A van Weerdenburg; Paul Tinnemans; Marco Tessari; Bernhard Blümich; Floris P J T Rutjes; Martin C Feiters
Journal:  Chemistry       Date:  2016-06-03       Impact factor: 5.236

10.  Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H NMR spectroscopy.

Authors:  Fernando Fernandez Diaz-Rullo; Francesco Zamberlan; Ryan E Mewis; Marianna Fekete; Lionel Broche; Lesley A Cheyne; Sergio Dall'Angelo; Simon B Duckett; Dana Dawson; Matteo Zanda
Journal:  Bioorg Med Chem       Date:  2017-03-21       Impact factor: 3.461
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