| Literature DB >> 25989481 |
Guo-Cui Wu1, Hai-Feng Pan1, Rui-Xue Leng1, De-Guang Wang2, Xiang-Pei Li3, Xiao-Mei Li3, Dong-Qing Ye1.
Abstract
Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).Entities:
Keywords: Autoimmune disease; Autoimmunity; Immune function; Noncoding RNA; lncRNA
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Year: 2015 PMID： 25989481 DOI： 10.1016/j.autrev.2015.05.004
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754