BACKGROUND: Finding the optimal location for the implantation of the electrode in deep brain stimulation (DBS) surgery is crucial for maximizing the therapeutic benefit to the patient. Such targeting is challenging for several reasons, including anatomic variability between patients as well as the lack of consensus about the location of the optimal target. OBJECTIVE: To compare the performance of popular manual targeting methods against a fully automatic nonrigid image registration-based approach. METHODS: In 71 Parkinson disease subthalamic nucleus (STN)-DBS implantations, an experienced functional neurosurgeon selected the target manually using 3 different approaches: indirect targeting using standard stereotactic coordinates, direct targeting based on the patient magnetic resonance imaging, and indirect targeting relative to the red nucleus. Targets were also automatically predicted by using a leave-one-out approach to populate the CranialVault atlas with the use of nonrigid image registration. The different targeting methods were compared against the location of the final active contact, determined through iterative clinical programming in each individual patient. RESULTS: Targeting by using standard stereotactic coordinates corresponding to the center of the motor territory of the STN had the largest targeting error (3.69 mm), followed by direct targeting (3.44 mm), average stereotactic coordinates of active contacts from this study (3.02 mm), red nucleus-based targeting (2.75 mm), and nonrigid image registration-based automatic predictions using the CranialVault atlas (2.70 mm). The CranialVault atlas method had statistically smaller variance than all manual approaches. CONCLUSION: Fully automatic targeting based on nonrigid image registration with the use of the CranialVault atlas is as accurate and more precise than popular manual methods for STN-DBS.
BACKGROUND: Finding the optimal location for the implantation of the electrode in deep brain stimulation (DBS) surgery is crucial for maximizing the therapeutic benefit to the patient. Such targeting is challenging for several reasons, including anatomic variability between patients as well as the lack of consensus about the location of the optimal target. OBJECTIVE: To compare the performance of popular manual targeting methods against a fully automatic nonrigid image registration-based approach. METHODS: In 71 Parkinson disease subthalamic nucleus (STN)-DBS implantations, an experienced functional neurosurgeon selected the target manually using 3 different approaches: indirect targeting using standard stereotactic coordinates, direct targeting based on the patient magnetic resonance imaging, and indirect targeting relative to the red nucleus. Targets were also automatically predicted by using a leave-one-out approach to populate the CranialVault atlas with the use of nonrigid image registration. The different targeting methods were compared against the location of the final active contact, determined through iterative clinical programming in each individual patient. RESULTS: Targeting by using standard stereotactic coordinates corresponding to the center of the motor territory of the STN had the largest targeting error (3.69 mm), followed by direct targeting (3.44 mm), average stereotactic coordinates of active contacts from this study (3.02 mm), red nucleus-based targeting (2.75 mm), and nonrigid image registration-based automatic predictions using the CranialVault atlas (2.70 mm). The CranialVault atlas method had statistically smaller variance than all manual approaches. CONCLUSION: Fully automatic targeting based on nonrigid image registration with the use of the CranialVault atlas is as accurate and more precise than popular manual methods for STN-DBS.
Authors: J Michael Fitzpatrick; Peter E Konrad; Chris Nickele; Ebru Cetinkaya; Chris Kao Journal: Stereotact Funct Neurosurg Date: 2005-04-08 Impact factor: 1.875
Authors: A L Benabid; A Koudsié; A Benazzouz; V Fraix; A Ashraf; J F Le Bas; S Chabardes; P Pollak Journal: Arch Med Res Date: 2000 May-Jun Impact factor: 2.235
Authors: Pierre-François D'Haese; Srivatsan Pallavaram; Chris Kao; Joseph S Neimat; Peter E Konrad; Benoit M Dawant Journal: Stereotact Funct Neurosurg Date: 2013-02-27 Impact factor: 1.875
Authors: Walter J Jermakowicz; Andres M Kanner; Samir Sur; Christina Bermudez; Pierre-Francois D'Haese; John Paul G Kolcun; Iahn Cajigas; Rui Li; Carlos Millan; Ramses Ribot; Enrique A Serrano; Naymee Velez; Merredith R Lowe; Gustavo J Rey; Jonathan R Jagid Journal: Epilepsia Date: 2017-02-28 Impact factor: 5.864
Authors: N C van Wouwe; S Pallavaram; F T Phibbs; D Martinez-Ramirez; J S Neimat; B M Dawant; P F D'Haese; K E Kanoff; W P M van den Wildenberg; M S Okun; S A Wylie Journal: Neuropsychologia Date: 2017-02-22 Impact factor: 3.139