Christopher A Sarkiss1, Guy A Fogg2, Branko Skovrlj3, Samuel K Cho4, John M Caridi3. 1. Icahn School of Medicine at Mount Sinai, Department of Neurosurgery, New York, USA. Electronic address: Christopher.sarkiss@mountsinai.org. 2. Saba University School of Medicine, Saba, Bonaire, Sint Eustatius and Saba. 3. Icahn School of Medicine at Mount Sinai, Department of Neurosurgery, New York, USA. 4. Icahn School of Medicine at Mount Sinai, Department of Orthopedic Surgery, New York, USA.
Abstract
INTRODUCTION: Degenerative spondylosis and kyphoscoliosis are increasingly recognized entities in patients with Parkinson's disease. Surgical treatment with spinal fusion can be complicated due to poor bone quality and muscular dysfunction in this patient population. The goal of this paper is to investigate surgical outcomes in Parkinson's patients undergoing spine surgery. METHODS: We performed a literature review using the PubMed and Google Scholar search engines investigating "Parkinson's disease and spinal fusion surgery" from the period of 2000 to 2013. The inclusion criteria included only English articles with Parkinson's patients that underwent spinal surgery. We identified and reviewed all six articles that included ninety-five patients with Parkinson's disease who underwent spinal surgery. RESULTS: A total of 95 patients with Parkinson's disease who underwent spinal fusion surgery were reviewed with average patient age of 69 and a 3:4 male to female ratio. With an average follow up of 40 months, 46 out of 73 patients (63%) were judged to have satisfactory outcomes with poor outcomes noted in the remaining 37%. These included but were not limited to pseudoarthrosis, hardware failure/pullout, development of adjacent level disease, persistent kyphosis or sagittal imbalance, and no improvement or worsening in their postoperative visual analog pain scale. There was a 45% (29/65) revision rate and a 59% (30/51) complication rate following the index procedure. CONCLUSION: It remains unclear whether Parkinson's patients benefit from spinal fusion surgery. Further prospective research is warranted to investigate surgical outcomes in this subset of patients.
INTRODUCTION:Degenerative spondylosis and kyphoscoliosis are increasingly recognized entities in patients with Parkinson's disease. Surgical treatment with spinal fusion can be complicated due to poor bone quality and muscular dysfunction in this patient population. The goal of this paper is to investigate surgical outcomes in Parkinson'spatients undergoing spine surgery. METHODS: We performed a literature review using the PubMed and Google Scholar search engines investigating "Parkinson's disease and spinal fusion surgery" from the period of 2000 to 2013. The inclusion criteria included only English articles with Parkinson'spatients that underwent spinal surgery. We identified and reviewed all six articles that included ninety-five patients with Parkinson's disease who underwent spinal surgery. RESULTS: A total of 95 patients with Parkinson's disease who underwent spinal fusion surgery were reviewed with average patient age of 69 and a 3:4 male to female ratio. With an average follow up of 40 months, 46 out of 73 patients (63%) were judged to have satisfactory outcomes with poor outcomes noted in the remaining 37%. These included but were not limited to pseudoarthrosis, hardware failure/pullout, development of adjacent level disease, persistent kyphosis or sagittal imbalance, and no improvement or worsening in their postoperative visual analog pain scale. There was a 45% (29/65) revision rate and a 59% (30/51) complication rate following the index procedure. CONCLUSION: It remains unclear whether Parkinson'spatients benefit from spinal fusion surgery. Further prospective research is warranted to investigate surgical outcomes in this subset of patients.
Authors: Roberta Arca; Valeria Ricchi; Daniela Murgia; Marta Melis; Francesco Floris; Alessandra Mereu; Paolo Contu; Francesco Marrosu; Maurizio Melis; Giovanni Cossu Journal: Neurol Sci Date: 2016-04-27 Impact factor: 3.307
Authors: Rafael De la Garza Ramos; C Rory Goodwin; Amit Jain; Daniel Martinez-Ramirez; Isaac O Karikari; Daniel M Sciubba Journal: J Spine Surg Date: 2017-12
Authors: Ivo D Dinov; Ben Heavner; Ming Tang; Gustavo Glusman; Kyle Chard; Mike Darcy; Ravi Madduri; Judy Pa; Cathie Spino; Carl Kesselman; Ian Foster; Eric W Deutsch; Nathan D Price; John D Van Horn; Joseph Ames; Kristi Clark; Leroy Hood; Benjamin M Hampstead; William Dauer; Arthur W Toga Journal: PLoS One Date: 2016-08-05 Impact factor: 3.240