Literature DB >> 25987617

Identification of New Natural CphA Metallo-β-Lactamases CphA4 and CphA5 in Aeromonas veronii and Aeromonas hydrophila Isolates from Municipal Sewage in Central Italy.

Carlo Bottoni1, Francesca Marcoccia1, Chiara Compagnoni1, Martina Colapietro1, Alessia Sabatini1, Giuseppe Celenza1, Bernardetta Segatore1, Maria Giovanna Maturo1, Gianfranco Amicosante1, Mariagrazia Perilli2.   

Abstract

Two new natural CphA metallo-β-lactamases, the CphA4 and CphA5 enzymes, were identified in water samples from municipal sewage in central Italy. Compared to CphA, the CphA4 and CphA5 enzymes showed numerous point mutations. These enzymes have a narrow spectrum of substrates focused on carbapenems only. CphA5 showed kcat values about 40-, 12-, and 97-fold higher than those observed for CphA4 versus imipenem, ertapenem, and biapenem, respectively.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25987617      PMCID： PMC4505251          DOI： 10.1128/AAC.00628-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France.

Authors:  Catherine Neuwirth; Eliane Siebor; Frederic Robin; Richard Bonnet
Journal:  Antimicrob Agents Chemother       Date:  2007-10-15       Impact factor: 5.191

Review 2.  The Aeromonas metallo-beta-lactamases: genetics, enzymology, and contribution to drug resistance.

Authors:  G M Rossolini; T Walsh; G Amicosante
Journal:  Microb Drug Resist       Date:  1996       Impact factor: 3.431

3.  Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.

Authors:  F De Meester; B Joris; G Reckinger; C Bellefroid-Bourguignon; J M Frère; S G Waley
Journal:  Biochem Pharmacol       Date:  1987-07-15       Impact factor: 5.858

Review 4.  Aeromonas spp. clinical microbiology and disease.

Authors:  Jennifer L Parker; Jonathan G Shaw
Journal:  J Infect       Date:  2010-12-14       Impact factor: 6.072

5.  Kinetic and spectroscopic characterization of native and metal-substituted beta-lactamase from Aeromonas hydrophila AE036.

Authors:  M Hernandez Valladares; M Kiefer; U Heinz; R P Soto; W Meyer-Klaucke; H F Nolting; M Zeppezauer; M Galleni; J M Frère; G M Rossolini; G Amicosante; H W Adolph
Journal:  FEBS Lett       Date:  2000-02-11       Impact factor: 4.124

6.  A metallo-beta-lactamase enzyme in action: crystal structures of the monozinc carbapenemase CphA and its complex with biapenem.

Authors:  Gianpiero Garau; Carine Bebrone; Christine Anne; Moreno Galleni; Jean-Marie Frère; Otto Dideberg
Journal:  J Mol Biol       Date:  2005-01-28       Impact factor: 5.469

7.  High specificity of cphA-encoded metallo-beta-lactamase from Aeromonas hydrophila AE036 for carbapenems and its contribution to beta-lactam resistance.

Authors:  B Segatore; O Massidda; G Satta; D Setacci; G Amicosante
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

8.  Phylogenetic diversity, antibiotic resistance and virulence traits of Aeromonas spp. from untreated waters for human consumption.

Authors:  Maria João Carvalho; Antonio Martínez-Murcia; Ana Cristina Esteves; António Correia; Maria José Saavedra
Journal:  Int J Food Microbiol       Date:  2012-09-23       Impact factor: 5.277

9.  Aeromonas hydrophila and Aeromonas veronii predominate among potentially pathogenic ciprofloxacin- and tetracycline-resistant aeromonas isolates from Lake Erie.

Authors:  Troy Skwor; Jasmine Shinko; Alexander Augustyniak; Christopher Gee; Greg Andraso
Journal:  Appl Environ Microbiol       Date:  2013-11-15       Impact factor: 4.792
  9 in total
  1 in total

1.  Proteomic Analysis Reveals That Metabolic Flows Affect the Susceptibility of Aeromonas hydrophila to Antibiotics.

Authors:  Zujie Yao; Wanxin Li; Yi Lin; Qian Wu; Feifei Yu; Wenxiong Lin; Xiangmin Lin
Journal:  Sci Rep       Date:  2016-12-19       Impact factor: 4.379
  1 in total

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