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Literature DB >> 2598759

Zollinger-Ellison syndrome in a patient with normal screening gastrin level.

R J Yanda¹, J W Ostroff, C D Ashbaugh, M S Guis, H I Goldberg.

Abstract

A 59-year-old female presented with multifocal peptic ulcer disease and diarrhea. A fasting serum gastrin level obtained while the patient was receiving no antacid therapy was normal. A secretin stimulation test was positive. A small gastrinoma was found in the anterior duodenal wall at exploratory laparotomy. Normal fasting gastrin levels do occur in patients with overt Zollinger-Ellison syndrome and should not deter further investigation if clinical suspicion of this syndrome is high.

Entities: Disease Gene Species

Mesh：

Substances：
Gastrins

Year: 1989 PMID： 2598759 DOI： 10.1007/bf01536714

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

15 in total

1. THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA.

Authors: R A GREGORY; H J TRACY
Journal: Gut Date: 1964-04 Impact factor: 23.059

2. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas.

Authors: R M ZOLLINGER; E H ELLISON
Journal: Ann Surg Date: 1955-10 Impact factor: 12.969

3. Natural history and experience with diagnosis and treatment of the Zollinger-Ellison syndrome.

Authors: J C Thompson; D D Reeder; H V Villar; H R Fender
Journal: Surg Gynecol Obstet Date: 1975-05

4. Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia.

Authors: M Feldman; L R Schiller; J H Walsh; J S Fordtran; C T Richardson
Journal: Gastroenterology Date: 1987-07 Impact factor: 22.682

5. Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumors of the Zollinger-Ellison variety.

Authors: J E McGuigan; W L Trudeau
Journal: N Engl J Med Date: 1968-06-13 Impact factor: 91.245

6. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats.

Authors: H Larsson; E Carlsson; H Mattsson; L Lundell; F Sundler; G Sundell; B Wallmark; T Watanabe; R Håkanson
Journal: Gastroenterology Date: 1986-02 Impact factor: 22.682

3. Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.

Authors: David C Metz; Guillaume Cadiot; Pierre Poitras; Tetsuhide Ito; Robert T Jensen
Journal: Int J Endocr Oncol Date: 2017-10-11

3 in total

Zollinger-Ellison syndrome in a patient with normal screening gastrin level.

1. THE CONSTITUTION AND PROPERTIES OF TWO GASTRINS EXTRACTED FROM HOG ANTRAL MUCOSA.

2. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas.

3. Natural history and experience with diagnosis and treatment of the Zollinger-Ellison syndrome.

4. Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia.

5. Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumors of the Zollinger-Ellison variety.

6. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats.

7. Serum gastrin levels before and after 6 weeks of cimetidine therapy in patients with duodenal ulcer.

Review 8. Zollinger-Ellison syndrome (gastrinoma). Current diagnosis and treatment.

9. The Zollinger-Ellison syndrome--23 years later.

10. Results of surgical management in 92 consecutive patients with Zollinger-Ellison syndrome.

1. [A young man with chronic diarrhea and epigastric pain].

Review 2. Diagnosis of Zollinger-Ellison syndrome: increasingly difficult.

3. Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing.