Literature DB >> 25987538

Models and mechanisms of vascular dementia.

Poornima Venkat1, Michael Chopp2, Jieli Chen3.   

Abstract

Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cognition; High fat diet; Multiple infarct dementia; Treatment; Vascular dementia

Mesh：

Year:  2015        PMID： 25987538      PMCID： PMC4631710          DOI： 10.1016/j.expneurol.2015.05.006

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  162 in total

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Authors:  Maggie Lai; Karen Horsburgh; Sung-Eun Bae; Roderick N Carter; Dirk J Stenvers; Jill H Fowler; Joyce L Yau; Celso E Gomez-Sanchez; Megan C Holmes; Christopher J Kenyon; Jonathan R Seckl; Malcolm R Macleod
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5.  The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling.

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Review 6.  Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders.

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Review 7.  The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

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8.  White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies.

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Review 9.  Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?

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