Manon Ranger1, Jill G Zwicker2, Cecil M Y Chau3, Min Tae M Park4, M Mallar Chakravarthy5, Kenneth Poskitt3, Steven P Miller6, Bruce H Bjornson1, Emily W Y Tam6, Vann Chau6, Anne R Synnes1, Ruth E Grunau7. 1. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada. 2. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada; Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, British Columbia, Canada. 3. Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada. 4. Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada; Douglas Mental Health University Institute, Montreal, Quebec, Canada. 5. Douglas Mental Health University Institute, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada. 6. Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada. 7. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Developmental Neurosciences and Child Health, Child and Family Research Institute, Vancouver, British Columbia, Canada. Electronic address: rgrunau@cw.bc.ca.
Abstract
OBJECTIVE: To examine whether specific neonatal factors differentially influence cerebellar subregional volumes and to investigate relationships between subregional volumes and outcomes in very preterm children at 7 years of age. STUDY DESIGN: Fifty-six children born very preterm (24-32 weeks gestational age) followed longitudinally from birth underwent 3-dimensional T(1)-weighted neuroimaging at median age 7.6 years. Children with severe brain injury were excluded. Cerebellar subregions were automatically segmented using the multiple automatically generated templates algorithm. The relation between cerebellum subregional volumes (adjusted for total brain volume and sex) and neonatal clinical factors were examined using constrained principal component analysis. Cognitive and visual-motor integration functions in relation to cerebellar volumes were also investigated. RESULTS: Higher neonatal procedural pain and infection, as well as other clinical factors, were differentially associated with reduced cerebellar volumes in specific subregions. After adjusting for clinical risk factors, neonatal procedural pain was distinctively associated with smaller volumes bilaterally in the posterior VIIIA and VIIIB lobules. Specific smaller cerebellar subregional volumes were related to poorer cognition and motor/visual integration. CONCLUSIONS: In very preterm children, exposure to painful procedures, as well as additional neonatal risk factors such as infection, were associated with reduced cerebellar volumes in specific subregions and poorer outcomes at school age.
OBJECTIVE: To examine whether specific neonatal factors differentially influence cerebellar subregional volumes and to investigate relationships between subregional volumes and outcomes in very preterm children at 7 years of age. STUDY DESIGN: Fifty-six children born very preterm (24-32 weeks gestational age) followed longitudinally from birth underwent 3-dimensional T(1)-weighted neuroimaging at median age 7.6 years. Children with severe brain injury were excluded. Cerebellar subregions were automatically segmented using the multiple automatically generated templates algorithm. The relation between cerebellum subregional volumes (adjusted for total brain volume and sex) and neonatal clinical factors were examined using constrained principal component analysis. Cognitive and visual-motor integration functions in relation to cerebellar volumes were also investigated. RESULTS: Higher neonatal procedural pain and infection, as well as other clinical factors, were differentially associated with reduced cerebellar volumes in specific subregions. After adjusting for clinical risk factors, neonatal procedural pain was distinctively associated with smaller volumes bilaterally in the posterior VIIIA and VIIIB lobules. Specific smaller cerebellar subregional volumes were related to poorer cognition and motor/visual integration. CONCLUSIONS: In very preterm children, exposure to painful procedures, as well as additional neonatal risk factors such as infection, were associated with reduced cerebellar volumes in specific subregions and poorer outcomes at school age.
Authors: M M Sperry; B M Kandel; S Wehrli; K N Bass; S R Das; P S Dhillon; J C Gee; G A Barr Journal: Neuroscience Date: 2017-04-06 Impact factor: 3.590
Authors: Jill G Zwicker; Steven P Miller; Ruth E Grunau; Vann Chau; Rollin Brant; Colin Studholme; Mengyuan Liu; Anne Synnes; Kenneth J Poskitt; Mikaela L Stiver; Emily W Y Tam Journal: J Pediatr Date: 2016-01-04 Impact factor: 4.406
Authors: Sophie Tremblay; Manon Ranger; Cecil M Y Chau; Jacob Ellegood; Jason P Lerch; Liisa Holsti; Daniel Goldowitz; Ruth E Grunau Journal: Pain Date: 2017-08 Impact factor: 7.926
Authors: Giulia Spoto; Greta Amore; Luigi Vetri; Giuseppe Quatrosi; Anna Cafeo; Eloisa Gitto; Antonio Gennaro Nicotera; Gabriella Di Rosa Journal: Front Syst Neurosci Date: 2021-06-10
Authors: Julia K Gundersen; Ela Chakkarapani; Sally Jary; David A Menassa; Emma Scull-Brown; Adam Frymoyer; Lars Walløe; Marianne Thoresen Journal: EClinicalMedicine Date: 2021-06-05