Literature DB >> 25987076

Radioactive seed implantation and lobaplatin chemotherapy are safe and effective in treating patients with advanced lung cancer.

Jia-Rui Li1, Yu Sun, Lin Liu.   

Abstract

UNLABELLED: Objecive: To investigate the clinical safety and efficacy of CT-guided 125iodine (125I) seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol in treating patients with advanced lung cancer.
MATERIALS AND METHODS: Patients with advanced lung cancer and treated with spiral CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol were recruited.
RESULTS: Of the 36 patients, there were 40 nidi in total. The contrast-enhanced CT evaluation was conducted 60 d after treatment. Response evaluation suggested that 4 patients achieved complete remission (CR), 24 partial remission (PR), 4 stable disease (SD) and 4 progression disease (PD), with a total response rate of 77.8% (28/36).
CONCLUSIONS: CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol are safe and effective in treating patients with advanced lung cancer.

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Year:  2015        PMID: 25987076     DOI: 10.7314/apjcp.2015.16.9.4003

Source DB:  PubMed          Journal:  Asian Pac J Cancer Prev        ISSN: 1513-7368


  4 in total

1.  The Mechanism of Computed Tomography-Guided 125I Particle in Treating Lung Cancer.

Authors:  Jianzhong Cheng; Shaozeng Ma; Guanghua Yang; Lisen Wang; Wei Hou
Journal:  Med Sci Monit       Date:  2017-01-17

2.  Lobaplatin Enhances Radioactive 125I Seed-Induced Apoptosis and Anti-Proliferative Effect in Non-Small Cell Lung Cancer by Suppressing the AKT/mTOR Pathway.

Authors:  Jia-Hui Rong; Dong Li; Yu-Liang Li
Journal:  Onco Targets Ther       Date:  2021-01-12       Impact factor: 4.147

3.  125I Seed Promotes Apoptosis in Non-small Lung Cancer Cells via the p38 MAPK-MDM2-p53 Signaling Pathway.

Authors:  Tao Zhang; ZhiQiang Mo; Guangfeng Duan; Rijie Tang; Fujun Zhang; Mingjian Lu
Journal:  Front Oncol       Date:  2021-04-21       Impact factor: 6.244

4.  Percutaneous biliary stent combined with brachytherapy using 125I seeds for treatment of unresectable malignant obstructive jaundice: A meta-analysis.

Authors:  Wei-Yue Chen; Chun-Li Kong; Miao-Miao Meng; Wei-Qian Chen; Li-Yun Zheng; Jian-Ting Mao; Shi-Ji Fang; Li Chen; Gao-Feng Shu; Yang Yang; Qiao-You Weng; Min-Jiang Chen; Min Xu; Jian-Song Ji
Journal:  World J Clin Cases       Date:  2021-12-16       Impact factor: 1.337

  4 in total

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