Literature DB >> 2598636

Effect of some metal ions on blood and liver delta-aminolevulinate dehydratase of Pimelodus maculatus (Pisces, Pimelodidae).

A L Rodrigues1, M L Bellinaso, T Dick.   

Abstract

1. delta-ALA-D from Pimelodus maculatus was inhibited in vitro by Cd2+ greater than Pb2+ greater than Hg2+ greater than Cu2+ greater than Zn2+ in blood and by Pb2+ greater than Cd2+ greater than Hg2+ greater than Cu2+ = Zn2+ in the liver. 2. Kinetic analysis of the inhibition by the metal ions showed that Cd2+ and Hg2+ act as non-competitive inhibitors on both sources. 3. Pb2+ showed a mixed type of inhibition in blood and a non-competitive type in the liver. 4. Zn2+ acted as a competitive or mixed inhibitor, on both sources, depending on concentration.

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Year:  1989        PMID： 2598636     DOI： 10.1016/0305-0491(89)90012-6

Source DB:  PubMed          Journal:  Comp Biochem Physiol B        ISSN： 0305-0491


  3 in total

1.  Interaction of metals from group 10 (Ni, Pd, and Pt) and 11 (Cu, Ag, and Au) with human blood δ-ALA-D: in vitro and in silico studies.

Authors:  Cláudia Vargas Klimaczewski; Pablo Andrei Nogara; Nilda Vargas Barbosa; João Batista Teixeira da Rocha
Journal:  Environ Sci Pollut Res Int       Date:  2018-09-01       Impact factor: 4.223

2.  Comparative studies on dicholesteroyl diselenide and diphenyl diselenide as antioxidant agents and their effect on the activities of Na+/K+ ATPase and delta-aminolevulinic acid dehydratase in the rat brain.

Authors:  Ige J Kade; Marcio W Paixão; Oscar E D Rodrigues; Nilda B V Barbosa; Antonio L Braga; Daiana S Avila; Cristina W Nogueira; João B T Rocha
Journal:  Neurochem Res       Date:  2007-08-21       Impact factor: 3.996

3.  Inhibition of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity in fish from waters affected by lead smelters.

Authors:  Christopher J Schmitt; Colleen A Caldwell; Bill Olsen; Dave Serdar; Mike Coffey
Journal:  Environ Monit Assess       Date:  2002-07       Impact factor: 2.513
  3 in total

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