Literature DB >> 25986249

Inhibitors of cellular kinases with broad-spectrum antiviral activity for hemorrhagic fever viruses.

Emma L Mohr1, Laura K McMullan2, Michael K Lo2, Jessica R Spengler2, Éric Bergeron2, César G Albariño2, Punya Shrivastava-Ranjan2, Cheng-Feng Chiang2, Stuart T Nichol2, Christina F Spiropoulou3, Mike Flint2.   

Abstract

Host cell kinases are important for the replication of a number of hemorrhagic fever viruses. We tested a panel of kinase inhibitors for their ability to block the replication of multiple hemorrhagic fever viruses. OSU-03012 inhibited the replication of Lassa, Ebola, Marburg and Nipah viruses, whereas BIBX 1382 dihydrochloride inhibited Lassa, Ebola and Marburg viruses. BIBX 1382 blocked both Lassa and Ebola virus glycoprotein-dependent cell entry. These compounds may be used as tools to understand conserved virus-host interactions, and implicate host cell kinases that may be targets for broad spectrum therapeutic intervention. Published by Elsevier B.V.

Entities:  

Keywords:  AR-12; Antiviral; BIBX; Ebola; Lassa

Mesh：

Substances：

Year:  2015        PMID： 25986249     DOI： 10.1016/j.antiviral.2015.05.003

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  34 in total

Review 1.  Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction.

Authors:  Giulia Torriani; Clara Galan-Navarro; Stefan Kunz
Journal:  J Virol       Date:  2017-01-31       Impact factor: 5.103

Review 2.  Targeted Therapies: Immunologic Effects and Potential Applications Outside of Cancer.

Authors:  Anna E Kersh; Spencer Ng; Yun Min Chang; Maiko Sasaki; Susan N Thomas; Haydn T Kissick; Gregory B Lesinski; Ragini R Kudchadkar; Edmund K Waller; Brian P Pollack
Journal:  J Clin Pharmacol       Date:  2017-11-14       Impact factor: 3.126

3.  Antifungal therapeutics for dimorphic fungal pathogens.

Authors:  Kristie D Goughenour; Chad A Rappleye
Journal:  Virulence       Date:  2016-09-19       Impact factor: 5.882

4.  4'-Azidocytidine (R1479) inhibits henipaviruses and other paramyxoviruses with high potency.

Authors:  Anne L Hotard; Biao He; Stuart T Nichol; Christina F Spiropoulou; Michael K Lo
Journal:  Antiviral Res       Date:  2017-06-17       Impact factor: 5.970

5.  Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus.

Authors:  Stephen R Welch; Florine E M Scholte; Mike Flint; Payel Chatterjee; Stuart T Nichol; Éric Bergeron; Christina F Spiropoulou
Journal:  Antiviral Res       Date:  2017-10-09       Impact factor: 5.970

6.  Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge.

Authors:  Ky V Hoang; Heather Curry; Michael A Collier; Hassan Borteh; Eric M Bachelder; Larry S Schlesinger; John S Gunn; Kristy M Ainslie
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

7.  The ReFRAME library as a comprehensive drug repurposing library to identify mammarenavirus inhibitors.

Authors:  Yu-Jin Kim; Beatrice Cubitt; Emily Chen; Mitchell V Hull; Arnab K Chatterjee; Yingyun Cai; Jens H Kuhn; Juan C de la Torre
Journal:  Antiviral Res       Date:  2019-07-11       Impact factor: 5.970

8.  Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses.

Authors:  C E Hulseberg; L Fénéant; K M Szymańska-de Wijs; N P Kessler; E A Nelson; C J Shoemaker; C S Schmaljohn; S J Polyak; J M White
Journal:  J Virol       Date:  2019-04-03       Impact factor: 5.103

9.  AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.

Authors:  Laurence Booth; Jane L Roberts; Heath Ecroyd; Sarah R Tritsch; Sina Bavari; St Patrick Reid; Stefan Proniuk; Alexander Zukiwski; Abraham Jacob; Claudia S Sepúlveda; Federico Giovannoni; Cybele C García; Elsa Damonte; Javier González-Gallego; María J Tuñón; Paul Dent
Journal:  J Cell Physiol       Date:  2016-06-06       Impact factor: 6.384

10.  Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.

Authors:  Joel Oppliger; Giulia Torriani; Antonio Herrador; Stefan Kunz
Journal:  J Virol       Date:  2016-06-24       Impact factor: 5.103
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