| Literature DB >> 25985278 |
Li Ping Lin1, Peng Yuan1, Nan Jiang2, Ya Ning Mei3, Wen Jing Zhang1, Hui Min Wu1, Ai Hua Zhang1, Jiang Ming Cao1, Zheng Xin Xiong2, Ye Lu, Ren Xiang Tan1.
Abstract
Dalesindole, an antibacterial and anti-inflammatory indole alkaloid with an undescribed carbon skeleton, was stereoselectively constructed by Daldinia eschscholzii through class II aldolase catalyzed Michael addition of fungal chromone with 3,3'-diindolylmethane (DIM) formed in situ from indole-3-carbinol (I3C) under catalyses of monooxygenase and 8-amino-7-oxononanoate synthase (AONS). Dalesindole isomerizes via a retro-Michael reaction to give stereoisomers with bioactivities. The work provides an access to new bioactive hybrids of fungal oligoketide with microbially decorated exogenous chemistry.Entities:
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Year: 2015 PMID： 25985278 DOI： 10.1021/acs.orglett.5b00882
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005