Wei-Han Wang1, Yang-Hsin Shih2,3, Hsiang-Yu Yu1,3, Der-Jen Yen1,3, Yung-Yang Lin1,3, Shang-Yeong Kwan1,3, Chien Chen1,3, Mau-Sun Hua4,5,6,7. 1. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. 2. Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. 3. National Yang-Ming University, Taipei, Taiwan. 4. Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. 5. Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan. 6. Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan. 7. Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan.
Abstract
OBJECTIVE: This study aimed to explore the effects of theory of mind (ToM) and related potential risk factors, including cognitive functions, psychiatric status, and seizure-related clinical variables, on social functioning in patients with temporal lobe epilepsy (TLE). METHODS: Sixty-seven patients with intractable TLE who were potential candidates for epilepsy surgery and 30 matched controls were included. All participants completed four tasks measuring different levels of ToM (False Belief, Faux Pas Recognition, Implication Stories, and Visual Cartoon), the Symptom Checklist-90-Revised (SCL-90-R), the Social and Occupational Functioning Scale for Epilepsy (SOFSE), and neuropsychological tests. RESULTS: The patients exhibited impairments in both basic and advanced ToM. Multiple regression analyses revealed the following: (1) the SOFSE total score was significantly predicted by the Faux Pas Recognition (FPR), Global Severity Index (GSI) score of the SCL-90-R, and Full-Scale intelligence quotient (IQ) of the Wechsler Adult Intelligence Scale (WAIS), which accounted for 38%, 11%, and 8% of the variance, respectively; and (2) the FPR was a significant predictor of all SOFSE subscales, whereas the GSI score contributed substantially to the Interpersonal Relationships, Communication, and Occupation subscales of the SOFSE. SIGNIFICANCE: Advanced ToM, measured by impaired faux pas recognition, is a relatively strong predictor of poor social functioning in surgical candidates for intractable TLE. Identifying ToM impairment may help plan nonpharmacologic treatment for improving social functions in patients with intractable TLE. Wiley Periodicals, Inc.
OBJECTIVE: This study aimed to explore the effects of theory of mind (ToM) and related potential risk factors, including cognitive functions, psychiatric status, and seizure-related clinical variables, on social functioning in patients with temporal lobe epilepsy (TLE). METHODS: Sixty-seven patients with intractable TLE who were potential candidates for epilepsy surgery and 30 matched controls were included. All participants completed four tasks measuring different levels of ToM (False Belief, Faux Pas Recognition, Implication Stories, and Visual Cartoon), the Symptom Checklist-90-Revised (SCL-90-R), the Social and Occupational Functioning Scale for Epilepsy (SOFSE), and neuropsychological tests. RESULTS: The patients exhibited impairments in both basic and advanced ToM. Multiple regression analyses revealed the following: (1) the SOFSE total score was significantly predicted by the Faux Pas Recognition (FPR), Global Severity Index (GSI) score of the SCL-90-R, and Full-Scale intelligence quotient (IQ) of the Wechsler Adult Intelligence Scale (WAIS), which accounted for 38%, 11%, and 8% of the variance, respectively; and (2) the FPR was a significant predictor of all SOFSE subscales, whereas the GSI score contributed substantially to the Interpersonal Relationships, Communication, and Occupation subscales of the SOFSE. SIGNIFICANCE: Advanced ToM, measured by impaired faux pas recognition, is a relatively strong predictor of poor social functioning in surgical candidates for intractable TLE. Identifying ToM impairment may help plan nonpharmacologic treatment for improving social functions in patients with intractable TLE. Wiley Periodicals, Inc.
Authors: Michele Morningstar; Andy Hung; Connor Grannis; Roberto C French; Whitney I Mattson; Adam P Ostendorf; Satyanarayana Gedela; Dario J Englot; Eric E Nelson Journal: Epilepsy Behav Date: 2020-09-09 Impact factor: 2.937
Authors: Jan Jastorff; Francois-Laurent De Winter; Jan Van den Stock; Rik Vandenberghe; Martin A Giese; Mathieu Vandenbulcke Journal: Hum Brain Mapp Date: 2016-08-11 Impact factor: 5.038