Susan J Pressler1, Marita Titler2, Todd M Koelling3, Penny L Riley2, Miyeon Jung2, Lisa Hoyland-Domenico2, David L Ronis2, Dean G Smith4, Barry E Bleske5, Susan G Dorsey6, Bruno Giordani7. 1. University of Michigan School of Nursing, Ann Arbor, Michigan. Electronic address: spressle@med.umich.edu. 2. University of Michigan School of Nursing, Ann Arbor, Michigan. 3. Division of Internal Medicine, Cardiology, University of Michigan School of Medicine, Ann Arbor, Michigan. 4. University of Michigan School of Public Health, Ann Arbor, Michigan. 5. University of Michigan College of Pharmacy, Ann Arbor, Michigan. 6. University of Maryland School of Nursing and Program in Neuroscience, Baltimore, Maryland. 7. Neuropsychology Section, Department of Psychiatry, Department of Neurology, Department of Psychology, and University of Michigan School of Nursing, Ann Arbor, Michigan.
Abstract
BACKGROUND: Memory loss is common in heart failure (HF) patients, but few interventions have been tested to treat it. The objective of this study was to evaluate efficacy of a cognitive training intervention, Brain Fitness, to improve memory, serum brain-derived neurotropic factor (BDNF) levels, working memory, processing speed, executive function, instrumental activities of daily living, mobility, depressive symptoms, and health-related quality of life. METHODS AND RESULTS:Twenty-seven HF patients were randomly assigned to Brain Fitness and health education active control interventions. Data were collected at baseline and 8 and 12 weeks. Linear mixed models analyses were completed. Patients in the Brain Fitness group were older with lower ejection fraction. At 12 weeks, a group by time interaction effect was found for serum BDNF levels (P = .011): serum BDNF levels increased among patients who completed Brain Fitness and decreased among patients who completed health education. No differences were found in memory, but a group by time interaction (P = .046) effect was found for working memory. CONCLUSIONS: Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients.
RCT Entities:
BACKGROUND:Memory loss is common in heart failure (HF) patients, but few interventions have been tested to treat it. The objective of this study was to evaluate efficacy of a cognitive training intervention, Brain Fitness, to improve memory, serum brain-derived neurotropic factor (BDNF) levels, working memory, processing speed, executive function, instrumental activities of daily living, mobility, depressive symptoms, and health-related quality of life. METHODS AND RESULTS: Twenty-seven HF patients were randomly assigned to Brain Fitness and health education active control interventions. Data were collected at baseline and 8 and 12 weeks. Linear mixed models analyses were completed. Patients in the Brain Fitness group were older with lower ejection fraction. At 12 weeks, a group by time interaction effect was found for serum BDNF levels (P = .011): serum BDNF levels increased among patients who completed Brain Fitness and decreased among patients who completed health education. No differences were found in memory, but a group by time interaction (P = .046) effect was found for working memory. CONCLUSIONS: Findings support efficacy of Brain Fitness in improving working memory and serum BDNF levels as a biomarker of intervention response. A randomized controlled study is needed among a larger more diverse group of HF patients.
Authors: Jordan M Harrison; Miyeon Jung; Terry A Lennie; Debra K Moser; Dean G Smith; Sandra B Dunbar; David L Ronis; Todd M Koelling; Bruno Giordani; Penny L Riley; Susan J Pressler Journal: J Clin Nurs Date: 2016-02-23 Impact factor: 3.036
Authors: Gayle G Page; Elizabeth J Corwin; Susan G Dorsey; Nancy S Redeker; Donna Jo McCloskey; Joan K Austin; Barbara J Guthrie; Shirley M Moore; Debra Barton; Miyong T Kim; Sharron L Docherty; Drenna Waldrop-Valverde; Donald E Bailey; Rachel F Schiffman; Angela Starkweather; Teresa M Ward; Suzanne Bakken; Kathleen T Hickey; Cynthia L Renn; Patricia Grady Journal: J Nurs Scholarsh Date: 2018-03-25 Impact factor: 3.176