Kristen M Couto1, M Cristina Iazbik2, Liliana M Marín1, Sara Zaldivar-López1, Melissa J Beal3, P Gómez Ochoa4, C Guillermo Couto1,5,4,6. 1. Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA. 2. The Ohio State University Veterinary Medical Center, Columbus, OH, USA. 3. IDEXX Laboratories, Westbrook, ME, USA. 4. Vetoclock Telemedicine, Zaragoza, Spain. 5. The Ohio State University College of Veterinary Medicine and Comprehensive Cancer Center, Columbus, OH, USA. 6. Couto Veterinary Consultants, Hilliard, OH, USA.
Abstract
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker whose plasma concentration is high in some dogs with cardiopulmonary disease. NT-proBNP is a diagnostic tool that can be used to help determine if a patient has congestive heart failure. Greyhounds have functional heart murmurs, relative cardiomegaly, and high serum cTnI concentration. OBJECTIVES: The purpose of the study was to evaluate the plasma concentration of NT-proBNP in healthy Greyhounds and compare it to non-Greyhound dogs. METHODS: We prospectively evaluated healthy client-owned dogs including retired racing Greyhounds and non-Greyhounds. Plasma was obtained and transferred into tubes containing a protease inhibitor and submitted for a specific NT-proBNP ELISA assay. RESULTS: The plasma NT-proBNP concentration in Greyhounds was significantly higher than in non-Greyhound control dogs (946 vs 632 pmol/L; P < .005); 46% of Greyhounds had NT-proBNP > 1000 pmol/L. CONCLUSIONS: Plasma NT-proBNP concentration in Greyhounds is high and should be interpreted with caution.
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker whose plasma concentration is high in some dogs with cardiopulmonary disease. NT-proBNP is a diagnostic tool that can be used to help determine if a patient has congestive heart failure. Greyhounds have functional heart murmurs, relative cardiomegaly, and high serum cTnI concentration. OBJECTIVES: The purpose of the study was to evaluate the plasma concentration of NT-proBNP in healthy Greyhounds and compare it to non-Greyhound dogs. METHODS: We prospectively evaluated healthy client-owned dogs including retired racing Greyhounds and non-Greyhounds. Plasma was obtained and transferred into tubes containing a protease inhibitor and submitted for a specific NT-proBNP ELISA assay. RESULTS: The plasma NT-proBNP concentration in Greyhounds was significantly higher than in non-Greyhound control dogs (946 vs 632 pmol/L; P < .005); 46% of Greyhounds had NT-proBNP > 1000 pmol/L. CONCLUSIONS: Plasma NT-proBNP concentration in Greyhounds is high and should be interpreted with caution.
Authors: Kendal E Harr; Sonya G Gordon; Ryan D Baumwart; Ross Feldgreber; Matthew R Spiro Journal: Vet Clin Pathol Date: 2022-03-20 Impact factor: 1.333
Authors: Sofia Hanås; Bodil S Holst; Katja Höglund; Jens Häggström; Anna Tidholm; Ingrid Ljungvall Journal: J Vet Intern Med Date: 2020-03-22 Impact factor: 3.333