| Literature DB >> 25982258 |
Anna Cipolletta Campanile1, Maria Gabriella Malzone, Veronica Sanna, Jessica Barizzi, Angela Manna, Antonella Gioioso, Annarosaria De Chiara, Franco Fulciniti.
Abstract
Merkel cell carcinoma (MCC) is an uncommon neuroendocrine small cell tumor derived from the transformation of the homonymous cells in the basal layer of the epidermis. MCC has a generally aggressive course, with a high tendency for local recurrence, lymph node involvement, and distant metastasis. Fine needle cytology (FNC) and immunocytochemistry were used as diagnostic procedures for 22 cases of MCC presented at our institute. All cases of MCC were successfully diagnosed on FNC. Among all of the monoclonal antisera used (CD56, CK20, CK MNF116, neuron-specific enolase (NSE), synaptophysin, and chromogranin), NSE and CD56 showed the highest frequency of positivity. The accuracy of the cytological diagnosis was 100% compared to the corresponding previous or subsequent pathological diagnoses. FNC and immunocytochemistry represent excellent and accurate diagnostic methods to distinguish MCC from other small-cell malignant entities.Entities:
Mesh：
Year: 2015 PMID： 25982258 DOI： 10.1007/s12022-015-9375-6
Source DB: PubMed Journal: Endocr Pathol ISSN： 1046-3976 Impact factor: 3.943