Sheng-long Lv1, Chen Fang1, Ji Hu2, Yun Huang2, Bo Yang1, Rong Zou1, Feng-yun Wang3, He-qing Zhao4. 1. Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China. 2. Department of Endocrinology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China. 3. Department of Pediatric, Soochow University Affiliated Children's Hospital, Suzhou 215004, China. 4. Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address: zhao_heqing@163.com.
Abstract
OBJECTIVE: The aim of this study is to evaluate the role of current perception threshold (CPT) measurement in peripheral neuropathy in type 1 diabetic patients by using the Neurometer(®), a nerve measuring instrument. METHODS: 52 patients with type 1 diabetes mellitus with a disease duration of less than five years and normal neuropathy symptom score (NSS), neuropathy disability score (NDS) and sensory nerve conduction velocity (SCV), and 40 healthy controls were enrolled in this study. Measurement of CPT using the Neurometer(®) at 2000, 250 and 5 Hz assesses function in the bilateral median nerve and sural nerve in all studied cases. We also evaluated the glycated hemoglobin, microalbuminuria, urinary albumin/creatinine ratio and other metabolism indexes of all patients. RESULTS: The CPT of the bilateral median nerve and sural nerve was significantly lower in diabetic patients (P<0.01). Moreover, the number of median nerve injuries in the diabetic group (left side 8/52, right side 8/52) is significantly different from the number of its ipsilateral sural nerve injuries (left side 28/52, right side 22/52) (left side P<0.01, right side P<0.01). By comparing those with DPN and those without DPN in the diabetic group, DPN groups had significantly higher glycated hemoglobin (t=2.518, P<0.05). Using binary logistic regression, high glycated hemoglobin was identified to be an independent risk factor of DPN incidence (OR (95% CI): 1.317 (1.013 -1.712), P<0.05). CONCLUSION: These data suggest that CPT is useful in early detection of peripheral neuropathy in patients with type 1 diabetes mellitus. Patients with diabetic peripheral neuropathy, the lower limb nerve is more vulnerable than the upper limb nerve. In addition, patients with DPN had higher glycated hemoglobin which is an independent risk factor of DPN.
OBJECTIVE: The aim of this study is to evaluate the role of current perception threshold (CPT) measurement in peripheral neuropathy in type 1 diabeticpatients by using the Neurometer(®), a nerve measuring instrument. METHODS: 52 patients with type 1 diabetes mellitus with a disease duration of less than five years and normal neuropathy symptom score (NSS), neuropathy disability score (NDS) and sensory nerve conduction velocity (SCV), and 40 healthy controls were enrolled in this study. Measurement of CPT using the Neurometer(®) at 2000, 250 and 5 Hz assesses function in the bilateral median nerve and sural nerve in all studied cases. We also evaluated the glycated hemoglobin, microalbuminuria, urinary albumin/creatinine ratio and other metabolism indexes of all patients. RESULTS: The CPT of the bilateral median nerve and sural nerve was significantly lower in diabeticpatients (P<0.01). Moreover, the number of median nerve injuries in the diabetic group (left side 8/52, right side 8/52) is significantly different from the number of its ipsilateral sural nerve injuries (left side 28/52, right side 22/52) (left side P<0.01, right side P<0.01). By comparing those with DPN and those without DPN in the diabetic group, DPN groups had significantly higher glycated hemoglobin (t=2.518, P<0.05). Using binary logistic regression, high glycated hemoglobin was identified to be an independent risk factor of DPN incidence (OR (95% CI): 1.317 (1.013 -1.712), P<0.05). CONCLUSION: These data suggest that CPT is useful in early detection of peripheral neuropathy in patients with type 1 diabetes mellitus. Patients with diabetic peripheral neuropathy, the lower limb nerve is more vulnerable than the upper limb nerve. In addition, patients with DPN had higher glycated hemoglobin which is an independent risk factor of DPN.
Authors: Jamie Burgess; Bernhard Frank; Andrew Marshall; Rashaad S Khalil; Georgios Ponirakis; Ioannis N Petropoulos; Daniel J Cuthbertson; Rayaz A Malik; Uazman Alam Journal: Diagnostics (Basel) Date: 2021-01-24
Authors: Anna Vágvölgyi; Ágnes Maróti; Mónika Szűcs; Csongor Póczik; Dóra Urbán-Pap; István Baczkó; Attila Nemes; Éva Csajbók; Krisztián Sepp; Péter Kempler; Andrea Orosz; Tamás Várkonyi; Csaba Lengyel Journal: Front Endocrinol (Lausanne) Date: 2021-08-27 Impact factor: 5.555
Authors: Fahmida Haque; Mamun B I Reaz; Muhammad E H Chowdhury; Serkan Kiranyaz; Sawal H M Ali; Mohammed Alhatou; Rumana Habib; Ahmad A A Bakar; Norhana Arsad; Geetika Srivastava Journal: Comput Intell Neurosci Date: 2022-04-25