Gido Bittermann1, Nicole Wiedenmann2, Andrei Bunea2, Steffen J Schwarz3, Anca-L Grosu2, Rainer Schmelzeisen3, Marc C Metzger3. 1. Department of Oral and Maxillofacial Surgery, University Medical Center Freiburg, Germany. Electronic address: gido.bittermann@uniklinik-freiburg.de. 2. Department of Radiation Oncology, University Medical Center Freiburg, Germany. 3. Department of Oral and Maxillofacial Surgery, University Medical Center Freiburg, Germany.
Abstract
BACKGROUND: Accurate tumour bed localisation is a key requirement for adjuvant radiotherapy. A new procedure is described for head and neck cancer treatment that improves tumour bed localisation using titanium clips. MATERIALS AND METHODS: Following complete local excision of the primary tumour, the tumour bed was marked with titanium clips. Preoperative gross target volume (GTV) and postoperative tumour bed were examined and the distances between the centres of gravity were evaluated. RESULTS: 49 patients with squamous cell carcinoma of the oral cavity were prospectively enrolled in this study. All patients underwent tumour resection, neck lymph node dissection and defect reconstruction in one stage. During surgery, 7-49 clips were placed in the resection cavity. Surgical clip insertion was successful in 88% (n=43). Clip identification and tumour bed delineation was successful in all 43 patients. The overall distance between the centres of gravity of the preoperative tumour extension to the tumour bed was 0.9cm. A significant relationship between the preoperative tumour extension and the postoperative tumour bed volume could be demonstrated. CONCLUSION: We demonstrate a precise delineation of the former tumour cavity. Improvements in tumour bed delineation allow an increase of accuracy for adjuvant treatment.
BACKGROUND: Accurate tumour bed localisation is a key requirement for adjuvant radiotherapy. A new procedure is described for head and neck cancer treatment that improves tumour bed localisation using titanium clips. MATERIALS AND METHODS: Following complete local excision of the primary tumour, the tumour bed was marked with titanium clips. Preoperative gross target volume (GTV) and postoperative tumour bed were examined and the distances between the centres of gravity were evaluated. RESULTS: 49 patients with squamous cell carcinoma of the oral cavity were prospectively enrolled in this study. All patients underwent tumour resection, neck lymph node dissection and defect reconstruction in one stage. During surgery, 7-49 clips were placed in the resection cavity. Surgical clip insertion was successful in 88% (n=43). Clip identification and tumour bed delineation was successful in all 43 patients. The overall distance between the centres of gravity of the preoperative tumour extension to the tumour bed was 0.9cm. A significant relationship between the preoperative tumour extension and the postoperative tumour bed volume could be demonstrated. CONCLUSION: We demonstrate a precise delineation of the former tumour cavity. Improvements in tumour bed delineation allow an increase of accuracy for adjuvant treatment.
Authors: David Steybe; Philipp Poxleitner; Pit Jacob Voss; Marc Christian Metzger; Rainer Schmelzeisen; Fabian Bamberg; Suam Kim; Maximilian Frederik Russe Journal: BMC Med Imaging Date: 2021-10-27 Impact factor: 1.930