Literature DB >> 25980034

Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.

Aase Berg1, Kari Otterdal2, Sam Patel3, Miguel Gonca3, Catarina David3, Ingvild Dalen4, Stig Nymo5, Margareta Nilsson6, Sofia Nordling7, Peetra U Magnusson7, Thor Ueland8, Mauro Prato9, Giuliana Giribaldi10, Tom Eirik Mollnes11, Pål Aukrust12, Nina Langeland13, Per H Nilsson6.   

Abstract

The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  C5a/C5aR1; IL-8/CXCL8; Plasmodium falciparum; complement activation; cytokines; heme; hemozoin; inflammation; malaria

Mesh：

Substances：

Year:  2015        PMID： 25980034     DOI： 10.1093/infdis/jiv283

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  10 in total

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Journal:  JCI Insight       Date:  2018-06-21

2.  Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood.

Authors:  Anub M Thomas; Alexandra Gerogianni; Martin B McAdam; Yngvar Fløisand; Corinna Lau; Terje Espevik; Per H Nilsson; Tom Eirik Mollnes; Andreas Barratt-Due
Journal:  J Immunol       Date:  2019-08-14       Impact factor: 5.422

3.  Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia.

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4.  The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites.

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Journal:  Infect Immun       Date:  2018-06-21       Impact factor: 3.441

Review 5.  New insights into microvascular injury to inform enhanced diagnostics and therapeutics for severe malaria.

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7.  Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner.

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Journal:  Front Immunol       Date:  2022-04-04       Impact factor: 8.786

Review 8.  Evaluating antidisease immunity to malaria and implications for vaccine design.

Authors:  Temitope W Ademolue; Gordon A Awandare
Journal:  Immunology       Date:  2017-12-26       Impact factor: 7.397

9.  Individualized Transcriptional Resolution of Complicated Malaria in a Colombian Study.

Authors:  Mónica L Rojas-Peña; Meixue Duan; Dalia Arafat; Lina Rengifo; Socrates Herrera; Myriam Arévalo-Herrera; Greg Gibson
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10.  Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria.

Authors:  Kari Otterdal; Aase Berg; Annika E Michelsen; Sam Patel; Ida Gregersen; Ellen Lund Sagen; Bente Halvorsen; Arne Yndestad; Thor Ueland; Nina Langeland; Pål Aukrust
Journal:  BMC Infect Dis       Date:  2020-01-21       Impact factor: 3.090
  10 in total

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