Giacomo Del Corso1, Davide Bartolomeo Gissi2, Achille Tarsitano3, Enrico Costabile3, Claudio Marchetti3, Lucio Montebugnoli2, Maria Pia Foschini4. 1. Department of Biomedical and Neuromotor Sciences, Section of Oral Science, University of Bologna, Italy. Electronic address: giacomo.delcorso@unibo.it. 2. Department of Biomedical and Neuromotor Sciences, Section of Oral Science, University of Bologna, Italy. 3. Department of Biomedical and Neuromotor Sciences, University of Bologna, Section of Maxillo-facial Surgery at Policlinico S. Orsola-Malpighi, Bologna, Italy. 4. Department of Biomedical and Neuromotor Sciences, Section of Anatomic Pathology at Bellaria Hospital, University of Bologna, Italy.
Abstract
OBJECTIVES: The study makes a comparison between two surgical approaches for the treatment of oral leukoplakia (OL) in terms of recurrence in a well-defined cohort of patients with a long-term follow-up period. METHODS: The cohort consisted of 77 OL patients divided into 2 groups. Group 1: 47 patients treated with laser evaporation using a Nd:YAG laser. Group 2: 30 patients treated with a CO2 laser for excision. Clinical and histological examinations were performed for the diagnosis of OL before treatment. We included OLs with or without dysplasia. The mean follow-up period was 60 ± 32.49 months. RESULTS: Of the 77 patients, 22 (28.5%) showed recurrence during the follow-up period. No significant difference was found between the two treatments (χ(2) = 2.6; p = 0.2). However, CO2 laser excision resulted in better results than the Nd:YAG laser evaporation, considering the non-homogeneous OLs (χ(2) = 3.9; p = 0.04) and OLs with mild dysplasia (χ(2) = 4.6; p = 0.03). DISCUSSION: The study makes a comparison between our results and articles from the literature, and suggests when each of the two surgical approaches is most appropriate.
OBJECTIVES: The study makes a comparison between two surgical approaches for the treatment of oral leukoplakia (OL) in terms of recurrence in a well-defined cohort of patients with a long-term follow-up period. METHODS: The cohort consisted of 77 OL patients divided into 2 groups. Group 1: 47 patients treated with laser evaporation using a Nd:YAG laser. Group 2: 30 patients treated with a CO2 laser for excision. Clinical and histological examinations were performed for the diagnosis of OL before treatment. We included OLs with or without dysplasia. The mean follow-up period was 60 ± 32.49 months. RESULTS: Of the 77 patients, 22 (28.5%) showed recurrence during the follow-up period. No significant difference was found between the two treatments (χ(2) = 2.6; p = 0.2). However, CO2 laser excision resulted in better results than the Nd:YAG laser evaporation, considering the non-homogeneous OLs (χ(2) = 3.9; p = 0.04) and OLs with mild dysplasia (χ(2) = 4.6; p = 0.03). DISCUSSION: The study makes a comparison between our results and articles from the literature, and suggests when each of the two surgical approaches is most appropriate.
Authors: L Monteiro; C Barbieri; S Warnakulasuriya; M Martins; F Salazar; J-J Pacheco; P Vescovi; M Meleti Journal: Med Oral Patol Oral Cir Bucal Date: 2017-09-01
Authors: Dorina Lauritano; Alberta Lucchese; Federica Gabrione; Dario Di Stasio; Javier Silvestre Rangil; Francesco Carinci Journal: Int J Environ Res Public Health Date: 2019-01-13 Impact factor: 3.390