Literature DB >> 25979393

Systemic therapy for squamous cell carcinoma of the head and neck.

Philip Pancari1, Ranee Mehra2.   

Abstract

The use of systemic therapy as part of curative treatment and palliation is an evolving paradigm for squamous cell cancer of the head and neck (SCCHN), which historically has been treated with local modalities. At present, the treatment armamentarium includes traditional cytotoxic therapy, targeted biological agents, and emerging immunotherapeutics. This article discusses the use of all of these systemic approaches for the curative and palliative treatment of SCCHN.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Chemoradiation; Epidermal growth factor receptor; Platinum chemotherapy; Squamous cell head and neck cancer

Mesh:

Substances:

Year:  2015        PMID: 25979393     DOI: 10.1016/j.soc.2015.03.004

Source DB:  PubMed          Journal:  Surg Oncol Clin N Am        ISSN: 1055-3207            Impact factor:   3.495


  6 in total

1.  Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.

Authors:  Ming Zhang; Ratnakar Singh; Shaohua Peng; Tuhina Mazumdar; Vaishnavi Sambandam; Li Shen; Pan Tong; Lerong Li; Nene N Kalu; Curtis R Pickering; Mitchell Frederick; Jeffrey N Myers; Jing Wang; Faye M Johnson
Journal:  Cancer Lett       Date:  2017-01-23       Impact factor: 8.679

2.  Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro.

Authors:  Jinsen Lu; Lele Wu; Xiaoke Wang; Jinhang Zhu; Juan Du; Bing Shen
Journal:  J Vis Exp       Date:  2018-07-17       Impact factor: 1.355

Review 3.  Progresses and Perspectives of Anti-PD-1/PD-L1 Antibody Therapy in Head and Neck Cancers.

Authors:  Bo Yang; Tingjun Liu; Yang Qu; Hangbo Liu; Song Guo Zheng; Bin Cheng; Jianbo Sun
Journal:  Front Oncol       Date:  2018-11-28       Impact factor: 6.244

4.  Proton Radiotherapy for Recurrent or Metastatic Head and Neck Cancers with Palliative Quad Shot.

Authors:  Jennifer Ma; Benjamin H Lok; Jingfeng Zong; Stanley I Gutiontov; Xin Cai; Andrew C Bell; Marina Shcherba; Han Xiao; Eric J Sherman; Chiaojung Jillian Tsai; Nadeem Riaz; Sean M McBride; Oren Cahlon; Nancy Y Lee
Journal:  Int J Part Ther       Date:  2018

5.  Downregulation of Microrna-126 Contributes to Tumorigenesis of Squamous Tongue Cell Carcinoma via Targeting KRAS.

Authors:  Jingying Han; Lina Wang; Xiaofeng Wang; Kun Li
Journal:  Med Sci Monit       Date:  2016-02-17

6.  Knockdown of CLIC4 enhances ATP-induced HN4 cell apoptosis through mitochondrial and endoplasmic reticulum pathways.

Authors:  Haowei Xue; Jinsen Lu; Renxiang Yuan; Jinli Liu; Yehai Liu; Kaile Wu; Jing Wu; Juan Du; Bing Shen
Journal:  Cell Biosci       Date:  2016-01-25       Impact factor: 7.133

  6 in total

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