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Literature DB >> 25979233

Cancer stem cells and their vascular niche: Do they benefit from each other?

Yi-Fang Ping¹, Xia Zhang², Xiu-Wu Bian³.

Abstract

Cancer stem cells (CSCs) locate in and interact with particular vascular niches to maintain their stemness. CSCs induce, remodel and participate in the formation of microenvironmental niches to facilitate survival, stemness and escape from radio-/chemo-/bio-therapies. Neovasculature in tumor is often basement membrane-deficient and enriched with CSC-derived endothelial cells (ECs) and other mural cells, which may promote tumor invasion and metastasis. The aim of this review is to summarize recent findings about the crosstalk between CSCs and their vascular niches and discuss the potential therapeutic significance.

Entities: Disease

Keywords: Cancer stem cells; Endothelial cells; Therapeutic significance; Tumor microenvironment; Vascular niches

Mesh：

Substances：

Year: 2015 PMID： 25979233 DOI： 10.1016/j.canlet.2015.05.010

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

16 in total

Review 1. Targeting cancer stem cell pathways for cancer therapy.

Authors: Liqun Yang; Pengfei Shi; Gaichao Zhao; Jie Xu; Wen Peng; Jiayi Zhang; Guanghui Zhang; Xiaowen Wang; Zhen Dong; Fei Chen; Hongjuan Cui
Journal: Signal Transduct Target Ther Date: 2020-02-07

2. PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.

Authors: Xue Liu; Qian Chen; Xu-Gang Hu; Xian-Chao Zhang; Ti-Wei Fu; Qing Liu; Yan Liang; Xi-Long Zhao; Xia Zhang; Yi-Fang Ping; Xiu-Wu Bian
Journal: Tumour Biol Date: 2016-07-27

3. Monitoring cancer stem cells: insights into clinical oncology.

Authors: ShuChen Lin; YingChun Xu; ZhiHua Gan; Kun Han; HaiYan Hu; Yang Yao; MingZhu Huang; DaLiu Min
Journal: Onco Targets Ther Date: 2016-02-11 Impact factor: 4.147

4. Metabolic shift in density-dependent stem cell differentiation.

Authors: Simar J Singh; William Turner; Drew E Glaser; Kara E McCloskey; Fabian V Filipp
Journal: Cell Commun Signal Date: 2017-10-20 Impact factor: 5.712

5. Cellular communication promotes mammosphere growth and collective invasion through microtubule‑like structures and angiogenesis.

Authors: Shangke Huang; Na Yuan; Guanying Wang; Fang Wu; Lu Feng; Minna Luo; Miao Li; Anqi Luo; Xinhan Zhao; Lingxiao Zhang
Journal: Oncol Rep Date: 2018-10-09 Impact factor: 3.906

6. Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation.

Authors: Lisha Ai; Shidai Mu; Chunyan Sun; Fengjuan Fan; Han Yan; You Qin; Guohui Cui; Yadan Wang; Tao Guo; Heng Mei; Huafang Wang; Yu Hu
Journal: Mol Cancer Date: 2019-04-13 Impact factor: 27.401

Cancer stem cells and their vascular niche: Do they benefit from each other?

Review 1. Targeting cancer stem cell pathways for cancer therapy.

2. PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT.

3. Monitoring cancer stem cells: insights into clinical oncology.

4. Metabolic shift in density-dependent stem cell differentiation.

5. Cellular communication promotes mammosphere growth and collective invasion through microtubule‑like structures and angiogenesis.

6. Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation.

Review 7. Proteases Regulate Cancer Stem Cell Properties and Remodel Their Microenvironment.

Review 8. Cancer stem cells and strategies for targeted drug delivery.

Review 9. Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets.

Review 10. Cancer Stem Cells and Its Role in Angiogenesis and Vasculogenic Mimicry in Gastrointestinal Cancers.